Exploring the role of secretory proteins in the human infectious diseases diagnosis and therapeutics.

3区生物学 Q1 Biochemistry, Genetics and Molecular Biology

Advances in protein chemistry and structural biology Pub Date : 2023-01-01 DOI:10.1016/bs.apcsb.2022.08.002

Elora Kalita, Mamta Panda, Abhishek Rao, Vijay Kumar Prajapati

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引用次数: 0

Abstract

Secretory proteins are playing important role during the host-pathogen interaction to develop the infection or protection into the cell. Pathogens developing infectious disease to human being are taken up by host macrophages or number of immune cells, play an important role in physiological, developmental and immunological function. At the same time, infectious agents are also secreting various proteins to neutralize the resistance caused by host cells and also helping the pathogens to develop the infection. Secretory proteins (secretome) are only developed at the time of host-pathogen interaction, therefore they become very important to develop the targeted and potential therapeutic strategies. Pathogen specific secretory proteins released during interaction with host cell provide opportunity to develop point of care and rapid diagnostic kits. Proteins secreted by pathogens at the time of interaction with host cell have also been found as immunogenic in nature and numbers of vaccines have been developed to control the spread of human infectious diseases. This chapter highlights the importance of secretory proteins in the development of diagnostic and therapeutic strategies to fight against human infectious diseases.

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探讨分泌蛋白在人类传染病诊断和治疗中的作用。

分泌蛋白在宿主-病原体相互作用中对细胞产生感染或保护作用起着重要作用。致人感染性疾病的病原体被宿主巨噬细胞或大量免疫细胞吸收，在生理、发育和免疫功能方面起着重要作用。与此同时，感染因子也分泌各种蛋白质来中和宿主细胞引起的抵抗，同时也帮助病原体发展感染。分泌蛋白(secretome)仅在宿主-病原体相互作用时产生，因此它们对开发靶向和潜在的治疗策略非常重要。病原体特异性分泌蛋白在与宿主细胞相互作用过程中释放，为开发护理点和快速诊断试剂盒提供了机会。病原体在与宿主细胞相互作用时分泌的蛋白质也被发现具有免疫原性，并且已经开发出许多疫苗来控制人类传染病的传播。本章强调了分泌蛋白在诊断和治疗策略的发展中的重要性，以对抗人类传染病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

7.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.