Exploring the macromolecules for secretory pathway in cancer disease.

3区生物学 Q1 Biochemistry, Genetics and Molecular Biology

Advances in protein chemistry and structural biology Pub Date : 2023-01-01 DOI:10.1016/bs.apcsb.2022.10.003

Chandrabose Selvaraj, Umesh Panwar, Karthik Raja Ramalingam, Rajendran Vijayakumar, Sanjeev Kumar Singh

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引用次数: 0

Abstract

Secretory proteins play an important role in the tumor microenvironment and are widely distributed throughout tumor tissues. Tumor cells secrete a protein that mediates communication between tumor cells and stromal cells, thereby controlling tumor growth and affecting the success of cancer treatments in the clinic. The cancer secretome is produced by various secretory pathways and has a wide range of applications in oncoproteomics. Secretory proteins are involved in cancer development and tumor cell migration, and thus serve as biomarkers or effective therapeutic targets for a variety of cancers. Several proteomic strategies have recently been used for the analysis of cancer secretomes in order to gain a better understanding and elaborate interpretation. For instance, the development of exosome proteomics, degradomics, and tumor-host cell interaction provide clear information regarding the mechanism of cancer pathobiology. In this chapter, we emphasize the recent advances in secretory protein and the challenges in the field of secretome analysis and their clinical applications.

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探索肿瘤疾病分泌途径的大分子。

分泌蛋白在肿瘤微环境中起着重要作用，广泛分布于肿瘤组织中。肿瘤细胞分泌一种蛋白质，介导肿瘤细胞与间质细胞之间的通讯，从而控制肿瘤生长，影响临床肿瘤治疗的成功与否。肿瘤分泌组由多种分泌途径产生，在肿瘤蛋白质组学中有着广泛的应用。分泌蛋白参与肿瘤的发展和肿瘤细胞的迁移，因此可以作为多种癌症的生物标志物或有效的治疗靶点。为了获得更好的理解和详细的解释，最近已经使用了几种蛋白质组学策略来分析癌症分泌组。例如，外泌体蛋白质组学、降解组学和肿瘤-宿主细胞相互作用的发展为癌症病理生物学机制提供了明确的信息。在这一章中，我们着重介绍了分泌蛋白的最新进展，以及在分泌组分析及其临床应用领域所面临的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

7.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.