Muscle Strength and Power in People With Parkinson Disease: A Systematic Review and Meta-analysis.

IF 2.6 3区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurologic Physical Therapy Pub Date : 2023-01-01 DOI:10.1097/NPT.0000000000000421

Mads Gamborg, Lars Grøndahl Hvid, Cecilie Thrue, Sverker Johansson, Erika Franzén, Ulrik Dalgas, Martin Langeskov-Christensen

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引用次数: 3

Abstract

Background and purpose: No studies have synthesized the literature regarding mechanical muscle function (ie, strength, power, rate of force development [RFD]) in people with Parkinson disease (PD). Here, we aimed to expand our understanding of mechanical muscle function in people with PD (PwPD) by systematically reviewing (1) the psychometric properties of isokinetic/isometric dynamometry in PD, (2) the literature comparing mechanical muscle function in PwPD with healthy controls (HC), and (3) reported associations between muscle mechanical muscle function and functional capacity and/or disease severity.

Methods: Systematic literature search in 6 databases. Included studies had to (1) enroll and report data on PwPD, (2) include assessment(s) of psychometric properties (ie, validity, reliability, responsiveness) of isokinetic/isometric dynamometry in PD, and/or (3) assess mechanical muscle function in both PwPD and HC using isokinetic/isometric dynamometry.

Results: A total of 40 studies were included. Aim 1 studies (n = 2) showed high reliability for isometric dynamometry (hip-abductor/dorsiflexor/trunk flexor-extensor/handgrip: intraclass correlations coefficients range = 0.92-0.98). Aim 2 studies (n = 40) showed impaired mechanical muscle function (ie, strength, power, RFD) in PwPD compared with HC (effect sizes range = 0.52-1.89). Aim 3 studies (n = 11) showed weak-to-strong associations between overall and lower extremities muscle strength and functional capacity and/or disease severity outcomes (ie, Unified Parkinson Disease Rating Scale).

Discussion and conclusions: Sparse methodological evidence suggests high reliability when using dynamometry in PwPD. Muscle strength, power, and RFD are impaired in PwPD compared with HC. Muscle strength is associated with functional capacity and disease severity.Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A403 ).

查看原文本刊更多论文

帕金森病患者的肌肉力量和力量:一项系统综述和荟萃分析。

背景与目的:目前尚未有文献对帕金森病(PD)患者的机械肌肉功能(即力量、动力、力发展率[RFD])进行综合研究。在这里，我们旨在通过系统地回顾(1)PD中等速/等速动力学的心理测量特性，(2)与健康对照(HC)比较PwPD患者机械肌肉功能的文献，以及(3)肌肉机械肌肉功能与功能容量和/或疾病严重程度之间的关联，来扩大我们对PD (PwPD)患者机械肌肉功能的理解。方法:对6个数据库进行系统文献检索。纳入的研究必须(1)登记和报告PwPD的数据，(2)包括评估PD中等速/等速动力学的心理测量特性(即效度，信度，反应性)，和/或(3)使用等速/等速动力学评估PwPD和HC的机械肌肉功能。结果:共纳入40项研究。目的1研究(n = 2)显示等距动力测量(髋外展肌/背屈肌/躯干屈伸肌/握力:类内相关系数范围= 0.92-0.98)具有高可靠性。目的2研究(n = 40)显示，与HC相比，PwPD患者的机械肌肉功能受损(即力量、功率、RFD)(效应值范围= 0.52-1.89)。目标3研究(n = 11)显示全身和下肢肌肉力量、功能能力和/或疾病严重程度结局(即统一帕金森病评定量表)之间有从弱到强的关联。讨论和结论:稀疏的方法学证据表明，在PwPD中使用动态测量法具有很高的可靠性。与HC相比，PwPD的肌力、力量和RFD受损。肌肉力量与功能能力和疾病严重程度有关。视频摘要可获得作者的更多见解(参见视频，补充数字内容1，可在:http://links.lww.com/JNPT/A403)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neurologic Physical Therapy CLINICAL NEUROLOGY-REHABILITATION

CiteScore

5.70

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Neurologic Physical Therapy (JNPT) is an indexed resource for dissemination of research-based evidence related to neurologic physical therapy intervention. High standards of quality are maintained through a rigorous, double-blinded, peer-review process and adherence to standards recommended by the International Committee of Medical Journal Editors. With an international editorial board made up of preeminent researchers and clinicians, JNPT publishes articles of global relevance for examination, evaluation, prognosis, intervention, and outcomes for individuals with movement deficits due to neurologic conditions. Through systematic reviews, research articles, case studies, and clinical perspectives, JNPT promotes the integration of evidence into theory, education, research, and practice of neurologic physical therapy, spanning the continuum from pathophysiology to societal participation.