Analysis of Mechanisms for Increased Blood Pressure Variability in Rats Continuously Infused with Angiotensin II.

IF 2.1 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE
Danfeng Jiang, Minami Matsuzaki, Yukiko Kawagoe, Kazuo Kitamura, Toshihiro Tsuruda, Koichi Kaikita, Yujiro Asada, Johji Kato
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引用次数: 0

Abstract

Objective: We reported that rats infused with angiotensin II (Ang II) are not only a model of hypertension but also of augmented 24 h blood pressure variability (BPV). In this study, we examined the mechanisms for Ang II-induced BPV, focusing on BP, heart rate (HR), baroreceptor reflex sensitivity (BRS), and medial area of the aortic arch.

Methods: Nine-week-old male Wistar rats were infused with subcutaneous 5.2 μg/kg/h Ang II with or without oral administration with 30 mg/kg/day azelnidipine for 14 days. BP and HR were recorded every 15 min under an unrestrained condition by a radiotelemetry system, while BPV was evaluated by standard deviation of BP. BRS was quantified by a sequence analysis, and medial thickness of the aortic arch was measured by microscopic examination.

Results: BPV increased at days 7 and 14 following continuous infusion of Ang II. Before the infusion, a positive correlation was found between BP and HR, but it became negative at day 7 and then weakened or disappeared at day 14. BRS was slightly impaired at day 7 and significantly lowered at day 14, a phenomenon accompanied by thickened medial area of the aortic arch in Ang II-infused rats. Those Ang II-induced alterations were all significantly attenuated by azelnidipine.

Conclusions: The present findings suggest sequential changes in the mechanisms behind augmented BPV in rats continuously infused with Ang II over 14 days.

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持续注入血管紧张素II后大鼠血压变异性升高的机制分析。
目的:我们报道了血管紧张素II (Ang II)灌注大鼠不仅是高血压模型,而且是24小时血压变异性(BPV)增强的模型。在这项研究中,我们研究了Ang ii诱导BPV的机制,重点关注血压、心率(HR)、压力受体反射敏感性(BRS)和主动脉弓内侧面积。方法:9周龄雄性Wistar大鼠皮下注射angii 5.2 μg/kg/h,同时或不同时口服azelnidipine 30 mg/kg/d,连续14 d。在不受约束的条件下,每15分钟用无线电遥测系统记录一次血压和心率,用血压的标准差评估BPV。通过序列分析量化BRS,显微检查测量主动脉弓内侧厚度。结果:连续输注Angⅱ后,BPV在第7天和第14天升高。灌注前血压与HR呈正相关,但在第7天变为负相关,第14天减弱或消失。第7天BRS轻度受损,第14天显著降低,并伴有主动脉弓内侧面积增厚。阿泽尼地平可显著减弱Angⅱ诱导的改变。结论:目前的研究结果表明,在持续输注Ang II超过14天的大鼠中,BPV增加的机制发生了顺序变化。
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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
16
审稿时长
6-12 weeks
期刊介绍: JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.
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