SIRPα: A key player in innate immunity

IF 4.5 3区医学 Q2 IMMUNOLOGY

European Journal of Immunology Pub Date : 2023-09-06 DOI:10.1002/eji.202350375

Yongyi Feng, Chunliu Huang, Yingzhao Wang, Jun Chen

引用次数: 0

Abstract

Signal regulatory protein alpha (SIRPα) is a crucial inhibitory regulator expressed on the surface of myeloid cells, including macrophages, dendritic cells, monocytes, neutrophils, and microglia. SIRPα plays an indispensable role in innate immune and adoptive immune responses in cancer immunology, tissue homeostasis, and other physiological or phycological conditions. This review provides an overview of the research history, ligands, signal transduction pathways, and functional mechanisms associated with SIRPα. Additionally, we summarize the therapeutic implications of targeting SIRPα as a promising novel strategy in immuno-oncology.

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SIRPα：先天免疫的关键因素。

信号调节蛋白α（SIRPα）是一种重要的抑制性调节因子，在骨髓细胞表面表达，包括巨噬细胞、树突状细胞、单核细胞、中性粒细胞和小胶质细胞。SIRPα在癌症免疫学、组织稳态和其他生理或病理条件下的先天免疫和过继免疫反应中发挥着不可或缺的作用。本文综述了SIRPα的研究历史、配体、信号转导途径和功能机制。此外，我们总结了靶向SIRPα作为免疫肿瘤学中一种有前途的新策略的治疗意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Immunology 医学-免疫学

CiteScore

8.30

自引率

3.70%

发文量

224

审稿时长

2 months

期刊介绍： The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.