Adjuvant role of Salvia miltiorrhiza bunge in cancer chemotherapy: A review of its bioactive components, health-promotion effect and mechanisms

IF 5.4 2区医学 Q1 CHEMISTRY, MEDICINAL

Journal of ethnopharmacology Pub Date : 2023-08-10 DOI:10.1016/j.jep.2023.117022

Jiayan Huang , Jiaojiao Zhang , Chengtao Sun , Ruiwen Yang , Miaomiao Sheng , Jiangning Hu , Guoyin Kai , Bing Han

{"title":"Adjuvant role of Salvia miltiorrhiza bunge in cancer chemotherapy: A review of its bioactive components, health-promotion effect and mechanisms","authors":"Jiayan Huang , Jiaojiao Zhang , Chengtao Sun , Ruiwen Yang , Miaomiao Sheng , Jiangning Hu , Guoyin Kai , Bing Han","doi":"10.1016/j.jep.2023.117022","DOIUrl":null,"url":null,"abstract":"<div><h3>Ethnopharmacological relevance</h3><p><span>Chemotherapy is a common cancer treatment strategy. However, its effectiveness is constrained by toxicity and adverse effects. The Lamiaceae herb </span><span><em>Salvia miltiorrhiza</em></span><span><span> Bunge has a long history of therapeutic use in the treatment of </span>blood stasis<span> illnesses, which are believed by traditional Chinese medicine to be connected to cancer.</span></span></p></div><div><h3>Aim of the study</h3><p>This review summarized the common toxicity of chemotherapy and the potential chemo-adjuvant effect and mechanisms of active ingredients from <em>S. miltiorrhiza</em>, hoping to provide valuable information for the development and application of <em>S. miltiorrhiza</em> resources.</p></div><div><h3>Materials and methods</h3><p>The literatures were retrieved from PubMed, Web of Science, Baidu Scholar and Google Scholar databases from 2002 to 2022. The inclusion criteria were studies reporting that <em>S. miltiorrhiza</em> or its constituents enhanced the efficiency of chemotherapy drugs or reduced the side effects.</p></div><div><h3>Results</h3><p><span><span>Salvianolic acid A, salvianolic acid B<span><span>, salvianolic acid C, rosmarinic acid, </span>tanshinone I, </span></span>tanshinone IIA<span>, cryptotanshinone, dihydrotanshinone I and miltirone are the primary adjuvant chemotherapy components of </span></span><em>S. miltiorrhiza</em><span>. The mechanisms mainly involve inhibiting proliferation, metastasis, and angiogenesis, inducing apoptosis, regulating autophagy and tumor microenvironment. In addition, they also improve chemotherapy drug-induced side effects.</span></p></div><div><h3>Conclusions</h3><p>The bioactive compounds of <em>S. miltiorrhiza</em> are shown to inhibit proliferation, metastasis, and angiogenesis, induce apoptosis and autophagy, regulate immunity and tumor microenvironment when combined with chemotherapy drugs. However, further clinical studies are required to validate the current studies.</p></div>","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":"318 ","pages":"Article 117022"},"PeriodicalIF":5.4000,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of ethnopharmacology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0378874123008905","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 3

Abstract

Ethnopharmacological relevance

Chemotherapy is a common cancer treatment strategy. However, its effectiveness is constrained by toxicity and adverse effects. The Lamiaceae herb Salvia miltiorrhiza Bunge has a long history of therapeutic use in the treatment of blood stasis illnesses, which are believed by traditional Chinese medicine to be connected to cancer.

Aim of the study

This review summarized the common toxicity of chemotherapy and the potential chemo-adjuvant effect and mechanisms of active ingredients from S. miltiorrhiza, hoping to provide valuable information for the development and application of S. miltiorrhiza resources.

Materials and methods

The literatures were retrieved from PubMed, Web of Science, Baidu Scholar and Google Scholar databases from 2002 to 2022. The inclusion criteria were studies reporting that S. miltiorrhiza or its constituents enhanced the efficiency of chemotherapy drugs or reduced the side effects.

Results

Salvianolic acid A, salvianolic acid B, salvianolic acid C, rosmarinic acid, tanshinone I, tanshinone IIA, cryptotanshinone, dihydrotanshinone I and miltirone are the primary adjuvant chemotherapy components of S. miltiorrhiza. The mechanisms mainly involve inhibiting proliferation, metastasis, and angiogenesis, inducing apoptosis, regulating autophagy and tumor microenvironment. In addition, they also improve chemotherapy drug-induced side effects.

Conclusions

The bioactive compounds of S. miltiorrhiza are shown to inhibit proliferation, metastasis, and angiogenesis, induce apoptosis and autophagy, regulate immunity and tumor microenvironment when combined with chemotherapy drugs. However, further clinical studies are required to validate the current studies.

Abstract Image

查看原文本刊更多论文

丹参在肿瘤化疗中的辅助作用:生物活性成分、促健康作用及机制综述

化疗是一种常见的癌症治疗策略。然而，其有效性受到毒性和不良反应的限制。丹参科草药丹参在治疗血瘀疾病方面有着悠久的历史，中医认为血瘀疾病与癌症有关。本文综述了丹参中常见的化疗毒性、潜在的化疗辅助作用及有效成分的作用机制，希望为丹参资源的开发利用提供有价值的信息。材料与方法检索2002 - 2022年的PubMed、Web of Science、百度Scholar和谷歌Scholar数据库中的文献。纳入标准是报道丹参或其成分提高化疗药物疗效或减少副作用的研究。结果丹酚酸A、丹酚酸B、丹酚酸C、迷迭香酸、丹参酮I、丹参酮IIA、隐丹参酮、二氢丹参酮I和米替龙是丹参的主要辅助化疗成分。其机制主要包括抑制增殖、转移和血管生成，诱导细胞凋亡，调节自噬和肿瘤微环境。此外，它们还能改善化疗药物引起的副作用。结论丹参具有抑制肿瘤细胞增殖、转移和血管生成、诱导细胞凋亡和自噬、调节免疫和肿瘤微环境等作用。然而，需要进一步的临床研究来验证当前的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of ethnopharmacology 医学-全科医学与补充医学

CiteScore

10.30

自引率

5.60%

发文量

967

审稿时长

77 days

期刊介绍： The Journal of Ethnopharmacology is dedicated to the exchange of information and understandings about people''s use of plants, fungi, animals, microorganisms and minerals and their biological and pharmacological effects based on the principles established through international conventions. Early people confronted with illness and disease, discovered a wealth of useful therapeutic agents in the plant and animal kingdoms. The empirical knowledge of these medicinal substances and their toxic potential was passed on by oral tradition and sometimes recorded in herbals and other texts on materia medica. Many valuable drugs of today (e.g., atropine, ephedrine, tubocurarine, digoxin, reserpine) came into use through the study of indigenous remedies. Chemists continue to use plant-derived drugs (e.g., morphine, taxol, physostigmine, quinidine, emetine) as prototypes in their attempts to develop more effective and less toxic medicinals.