Antimicrobial Peptides Therapy: An Emerging Alternative for Treating Drug-Resistant Bacteria.

IF 2.5 3区 工程技术 Q2 BIOLOGY
Yale Journal of Biology and Medicine Pub Date : 2022-12-01
Ifeanyi Elibe Mba, Emeka Innocent Nweze
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引用次数: 0

Abstract

Microbial resistance to antibiotics is an ancient and dynamic issue that has brought a situation reminiscent of the pre-antibiotic era to the limelight. Currently, antibiotic resistance and the associated infections are widespread and pose significant global health and economic burden. Thus, the misuse of antibiotics, which has increased resistance, has necessitated the search for alternative therapeutic agents for combating resistant pathogens. Antimicrobial peptides (AMPs) hold promise as a viable therapeutic approach against drug-resistant pathogens. AMPs are oligopeptides with low molecular weight. They have broad-spectrum antimicrobial activities against pathogenic microorganisms. AMPs are nonspecific and target components of microbes that facilitate immune response by acting as the first-line defense mechanisms against invading pathogenic microbes. The diversity and potency of AMPs make them good candidates for alternative use. They could be used alone or in combination with several other biomaterials for improved therapeutic activity. They can also be employed in vaccine production targeting drug-resistant pathogens. This review covers the opportunities and advances in AMP discovery and development targeting antimicrobial resistance (AMR) bacteria. Briefly, it presents an overview of the global burden of the antimicrobial resistance crisis, portraying the global magnitude, challenges, and consequences. After that, it critically and comprehensively evaluates the potential roles of AMPs in addressing the AMR crisis, highlighting the major potentials and prospects.

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抗菌肽疗法:治疗耐药细菌的新选择。
微生物对抗生素的耐药性是一个古老而动态的问题,它使人们想起抗生素出现前的时代。目前,抗生素耐药性和相关感染广泛存在,并构成重大的全球健康和经济负担。因此,抗生素的滥用增加了耐药性,因此有必要寻找替代治疗药物来对抗耐药病原体。抗菌肽(AMPs)有望成为对抗耐药病原体的可行治疗方法。amp是低分子量的寡肽。它们对病原微生物具有广谱抗菌活性。amp是微生物的非特异性靶标成分,通过作为抵抗入侵病原微生物的第一线防御机制促进免疫反应。amp的多样性和效力使其成为替代使用的良好候选者。它们可以单独使用或与其他几种生物材料联合使用,以提高治疗活性。它们也可用于针对耐药病原体的疫苗生产。本文综述了针对抗菌素耐药性(AMR)细菌的AMP发现和开发的机遇和进展。简而言之,它概述了抗菌素耐药性危机的全球负担,描绘了全球规模、挑战和后果。然后,批判性和全面地评估amp在解决AMR危机中的潜在作用,突出主要潜力和前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Yale Journal of Biology and Medicine
Yale Journal of Biology and Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.00
自引率
0.00%
发文量
41
期刊介绍: The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.
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