The effects of Artemisia absinthium L. on scopolamine-induced learning and memory impairment and brain tissue oxidative damage in adult rats.

IF 1.9 Q3 CHEMISTRY, MEDICINAL
Marzieh Rahimi, Narges Marefati, Farimah Beheshti, Somaieh Ahmadabady, Hassan Rakhshandeh, Mahmoud Hosseini
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引用次数: 0

Abstract

Objective: The present study examined the effects of Artemisia absinthium L. on scopolamine-induced memory dysfunction and brain tissue oxidative damage in rats.

Materials and methods: Fifty rats were used in five groups: Control: received dimethyl sulfoxide (DMSO)/saline, Scopolamine: scopolamine (2 mg/kg) was administered along with DMSO/saline, and Scopolamine-Ext 50, Scopolamine-Ext 100, and Scopolamine-Ext 200 groups: A. absinthium hydroalcoholic extract 50, 100 and 200 mg/kg were administered before scopolamine. The Morris water maze (MWM) and passive avoidance (PA) tasks were used for assessment of behavioral parameters. Malondialdehyde (MDA), nitric oxide (NO) metabolites, total thiol, catalase (CAT), and superoxide dismutase (SOD) were measured in the cortex and hippocampus.

Results: A. absinthium decreased the delay time and distance traveled to reach the platform in the MWM test (p<0.05-p<0.001). Besides, the extract increased the delay time to pass in the dark and the light time while decreasing the number of entrances and the dark time in the PA task (p<0.05-p<0.001). In biochemical assessments, A. absinthium attenuated NO metabolites (p<0.001) and MDA (p<0.05- p<0.001) while enhanced total thiol (p<0.001), CAT and SOD (both p<0.05-p<0.001).

Conclusion: This study revealed that A. absinthium improved memory and learning impairment and brain tissue oxidative damage in scopolamine-treated rats.

Abstract Image

Abstract Image

Abstract Image

苦艾对东莨菪碱所致成年大鼠学习记忆障碍及脑组织氧化损伤的影响。
目的:研究苦艾对东莨菪碱所致大鼠记忆功能障碍和脑组织氧化损伤的影响。材料和方法:50只大鼠分为5组:对照组:接受二甲基亚砜(DMSO)/生理盐水,东莨菪碱:东莨菪碱(2mg/kg)与DMSO/生理盐水一起给药,东莨菪碱Ext 50、东莨菪碱Ext100和东莨菪碱Ext200组:在东莨菪碱之前给药苦艾水醇提取物50、100和200mg/kg。Morris水迷宫(MWM)和被动回避(PA)任务用于评估行为参数。测定皮层和海马丙二醛(MDA)、一氧化氮(NO)代谢产物、总硫醇、过氧化氢酶(CAT)和超氧化物歧化酶(SOD)。结果:苦艾在MWM试验中减少了到达平台的延迟时间和距离(pA.苦艾减弱了NO代谢产物)。结论:本研究表明,苦艾改善了东莨菪碱治疗大鼠的记忆和学习障碍以及脑组织氧化损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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