Translational toxicology in zebrafish

IF 4.6
Tamara Tal , Bianca Yaghoobi , Pamela J. Lein
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引用次数: 28

Abstract

A major goal of translational toxicology is to identify adverse chemical effects and determine whether they are conserved or divergent across experimental systems. Translational toxicology encompasses assessment of chemical toxicity across multiple life stages, determination of toxic mode of action, computational prediction modeling, and identification of interventions that protect or restore health after toxic chemical exposures. The zebrafish is increasingly used in translational toxicology because it combines the genetic and physiological advantages of mammalian models with the higher-throughput capabilities and genetic manipulability of invertebrate models. Here, we review the recent literature demonstrating the power of the zebrafish as a model for addressing all four activities of translational toxicology. Important data gaps and challenges associated with using zebrafish for translational toxicology are also discussed.

斑马鱼的转化毒理学
翻译毒理学的一个主要目标是确定不利的化学效应,并确定它们在实验系统中是保守的还是发散的。转化毒理学包括评估化学物质在多个生命阶段的毒性,确定毒性作用模式,计算预测模型,以及确定有毒化学物质暴露后保护或恢复健康的干预措施。斑马鱼越来越多地用于翻译毒理学,因为它结合了哺乳动物模型的遗传和生理优势以及无脊椎动物模型的高通量能力和遗传可操作性。在这里,我们回顾了最近的文献,证明了斑马鱼作为解决翻译毒理学所有四个活动的模型的力量。重要的数据差距和挑战与使用斑马鱼翻译毒理学也进行了讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current opinion in toxicology
Current opinion in toxicology Toxicology, Biochemistry
CiteScore
8.50
自引率
0.00%
发文量
0
审稿时长
64 days
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