Characteristics and sources of tissue-resident memory T cells in psoriasis relapse

Q4 Immunology and Microbiology

Current research in immunology Pub Date : 2023-01-01 DOI:10.1016/j.crimmu.2023.100067

Canbin Dong , Lanmei Lin , Juan Du

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引用次数: 1

Abstract

Tissue-resident memory T cells (Trm) are a sub-population of memory T cells that reside in skin tissue. Recent studies have revealed potential role of Trm in the reoccurrence of psoriasis, as these cells tend to be profusely infiltrated in the lesions observed during psoriasis relapse. Trm can be classified into CD8⁺ Trm cells that are distributed mainly in the epidermis and CD4⁺ Trm cells in the dermis. CD8⁺ Trm is derived from circulating memory T cells and CD49a⁻CD8⁺ Trm takes a crucial role in psoriasis relapse. In contrast, CD4⁺ Trm may originate from exTh17 cells and exTreg cells emerging from the inflammatory process. Since IL-23 can activate Trm, neutralizing antibodies against IL-23 are suggested to be more effective in clinical treatment. This review will focus on Trm cells in psoriasis relapsed lesions to reveal their mechanisms in the pathogenesis, relapse and transformation of psoriasis.

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银屑病复发组织驻留记忆T细胞的特征和来源

组织驻留记忆T细胞（Trm）是驻留在皮肤组织中的记忆T细胞的亚群。最近的研究揭示了Trm在银屑病复发中的潜在作用，因为在银屑病复发期间观察到的病变中，这些细胞往往大量浸润。Trm可分为主要分布在表皮中的CD8+Trm细胞和真皮中的CD4+Trm细胞。CD8+Trm来源于循环记忆T细胞，CD49a−CD8+Trm在银屑病复发中起着至关重要的作用。相反，CD4+Trm可能来源于炎症过程中出现的exTh17细胞和exTreg细胞。由于IL-23可以激活Trm，因此抗IL-23的中和抗体在临床治疗中更有效。本文就Trm细胞在银屑病复发性病变中的作用机制进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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