Incidental Papillary Microcarcinoma and Papillary Thyroid Carcinoma in Multinodular Goiter.

IF 2.6 4区医学 Q3 CELL BIOLOGY

Analytical Cellular Pathology Pub Date : 2023-01-01 DOI:10.1155/2023/2768344

Cigdem D Arican, Tulin Ozturk, Muhammet Sait Sager, Ipek Sertbudak, Serkan Teksoz, Cansu Turker Saricoban, Abdulkerim Uygur

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Abstract

Introduction: This study aimed to examine the incidence of incidental papillary microcarcinoma (PMC) and papillary thyroid carcinoma (PTC) in patients with benign multinodular goiter (MNG) and to compare their relationship with some prognostic factors from a new perspective.

Methods: Bilateral total thyroidectomy (BTT) was used to evaluate the data of 716 patients who underwent a surgery for MNG. The prognostic data for these tumors and the relationship between patients with bilateral and multifocal tumors were evaluated using statistical tests.

Results: Papillary carcinomas were detected in 201 patients, PMC in 134 of them, and PTCs in 67. Bilaterality was more common in patients with PTCs than in those with PMC. The incidence of bilaterality in male patients with PTC was statistically more common. The presence of intra-tumoral lymphocytes was higher in multifocal PTC cases than in unifocal PTC cases.

Conclusion: The results revealed that the number of PMC s was high in incidental tumors, and patients with PTC with male sex, bilaterality, multifocality, and tumor capsule invasion were associated with poor prognosis.

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多结节性甲状腺肿伴发乳头状微癌和甲状腺乳头状癌。

前言:本研究旨在从新的角度探讨良性多结节性甲状腺肿(MNG)患者偶发微乳头状癌(PMC)和甲状腺乳头状癌(PTC)的发生率，并比较其与一些预后因素的关系。方法:采用双侧甲状腺全切除术(BTT)对716例MNG手术患者的资料进行评价。这些肿瘤的预后数据以及双侧和多灶性肿瘤患者之间的关系使用统计检验进行评估。结果:201例患者检出乳头状癌，其中PMC 134例，ptc 67例。双侧性在ptc患者中比PMC患者更常见。男性PTC患者双侧双侧的发生率在统计学上更为常见。多灶性PTC患者肿瘤内淋巴细胞的存在高于单灶性PTC患者。结论:PMC在偶发肿瘤中数量较多，男性、双侧、多灶性、肿瘤包膜浸润的PTC患者预后较差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Analytical Cellular Pathology ONCOLOGY-CELL BIOLOGY

CiteScore

4.90

自引率

3.10%

发文量

审稿时长

16 weeks

期刊介绍： Analytical Cellular Pathology is a peer-reviewed, Open Access journal that provides a forum for scientists, medical practitioners and pathologists working in the area of cellular pathology. The journal publishes original research articles, review articles, and clinical studies related to cytology, carcinogenesis, cell receptors, biomarkers, diagnostic pathology, immunopathology, and hematology.