FamilyCoviDD19: results of a cross-sectional study-long-term outcomes of infected and uninfected household members.

IF 2.6 3区医学 Q1 PRIMARY HEALTH CARE

Family Medicine and Community Health Pub Date : 2023-09-01 DOI:10.1136/fmch-2022-002057

Theresa S Horst, Jakob P Armann, Maren Doenhardt, Svenja Dreßen, Paula Czyborra, Josephine Schneider, Christin Gano, Alexander Dalpke, Christian Lück, Annet Bluschke, Magdalena Wekenborg, Reinhard Berner, Judith Blankenburg

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Abstract

Objective: In this study, we aimed to compare long-term physical and mental health outcome between SARS-CoV-2 infected and uninfected household members to differentiate between infection-related and pandemic-related outcomes after about two and a half years of the pandemic. Furthermore, possible differences in the outcome of adults and children and young people (CYP) were of interest.

Design: In a cross-sectional study design, we compared the long-term physical and mental health outcome of between infected and uninfected as well as between adult and CYP (household members).

Setting: The FamilyCoviDD19 study-a serology study in households-was initially conducted to evaluate virus transmission in a close contact setting focusing on households with children and adolescents in Germany. At least 1 year after initial infection in the respective households, a follow-up took place in which the prevalence and type of possible long-term consequences were surveyed on the basis of self-reported information on physical and mental health.

Participant: In this study, a total of 533 household members of 146 families participated and responded to our survey, including 296 (55.5%) adults and 237 (44.5%) CYP.

Result: The difference in frequency of reported symptoms between infected and uninfected individuals was very moderate, suggesting that the vast majority of reported symptoms were not attributable to a previous SARS-CoV-2 infection. However, regardless of age and infection status, this study showed overall high rates of self-reported symptoms with CYP having fewer long-term sequelae than adults one year after infection. Furthermore, over 50% of those reporting symptoms were not affected in their daily life, with CYPs reporting an even lower percentage compared with adults.

Conclusion: CYP are at reduced risk not only to develop symptomatic infection or severe disease courses (previous analyses) but also to develop infection-associated long-term sequelae (this study). Independent of infection CYP reported high rates of neurocognitive, pain, somatic and mood symptoms, which makes the influence of the pandemic itself-including pandemic control measures-decisive.

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familycovid - 19:一项横断面研究的结果——感染和未感染家庭成员的长期结果。

目的:在本研究中，我们旨在比较SARS-CoV-2感染和未感染家庭成员之间的长期身心健康结果，以区分大流行大约两年半后感染相关和大流行相关的结果。此外，成人和儿童及青少年(CYP)的结果可能存在的差异令人感兴趣。设计:在横断面研究设计中，我们比较了感染和未感染以及成人和家庭成员之间的长期身心健康结果。环境:家庭covid - 19研究——一项家庭血清学研究——最初是为了评估密切接触环境中的病毒传播，重点是德国有儿童和青少年的家庭。在各自家庭初次感染后至少1年，进行了一次随访，根据自我报告的身体和心理健康信息，调查了流行率和可能的长期后果类型。参与者:本研究共有146个家庭的533名家庭成员参与并回复了我们的调查，其中成人296人(55.5%)，青少年237人(44.5%)。结果:感染者和未感染者报告的症状频率差异非常温和，这表明绝大多数报告的症状不是由于以前的SARS-CoV-2感染引起的。然而，无论年龄和感染状况如何，该研究显示，总体而言，CYP患者自我报告症状的比例较高，感染一年后的长期后遗症比成人少。此外，超过50%的报告症状的人在日常生活中没有受到影响，与成年人相比，报告的CYPs比例更低。结论:CYP不仅发生症状性感染或严重病程(先前的分析)的风险较低，而且发生感染相关的长期后遗症(本研究)的风险也较低。与感染无关，CYP报告的神经认知、疼痛、躯体和情绪症状发生率很高，这使得大流行本身(包括大流行控制措施)的影响具有决定性。

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来源期刊

Family Medicine and Community Health PRIMARY HEALTH CARE-

CiteScore

9.70

自引率

0.00%

发文量

审稿时长

19 weeks

期刊介绍： Family Medicine and Community Health (FMCH) is a peer-reviewed, open-access journal focusing on the topics of family medicine, general practice and community health. FMCH strives to be a leading international journal that promotes ‘Health Care for All’ through disseminating novel knowledge and best practices in primary care, family medicine, and community health. FMCH publishes original research, review, methodology, commentary, reflection, and case-study from the lens of population health. FMCH’s Asian Focus section features reports of family medicine development in the Asia-pacific region. FMCH aims to be an exemplary forum for the timely communication of medical knowledge and skills with the goal of promoting improved health care through the practice of family and community-based medicine globally. FMCH aims to serve a diverse audience including researchers, educators, policymakers and leaders of family medicine and community health. We also aim to provide content relevant for researchers working on population health, epidemiology, public policy, disease control and management, preventative medicine and disease burden. FMCH does not impose any article processing charges (APC) or submission charges.