Significance of understanding the genomics of host-pathogen interaction in limiting antibiotic resistance development: lessons from COVID-19 pandemic.

IF 2.5 3区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Briefings in Functional Genomics Pub Date : 2024-01-18 DOI:10.1093/bfgp/elad001

Vikas Yadav, Srividhya Ravichandran

引用次数: 0

Abstract

The entire world is facing the stiff challenge of COVID-19 pandemic. To overcome the spread of this highly infectious disease, several short-sighted strategies were adopted such as the use of broad-spectrum antibiotics and antifungals. However, the misuse and/or overuse of antibiotics have accentuated the emergence of the next pandemic: antimicrobial resistance (AMR). It is believed that pathogens while transferring between humans and the environment carry virulence and antibiotic-resistant factors from varied species. It is presumed that all such genetic factors are quantifiable and predictable, a better understanding of which could be a limiting step for the progression of AMR. Herein, we have reviewed how genomics-based understanding of host-pathogen interactions during COVID-19 could reduce the non-judicial use of antibiotics and prevent the eruption of an AMR-based pandemic in future.

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了解宿主与病原体相互作用的基因组学对限制抗生素耐药性发展的意义：从 COVID-19 大流行中汲取的教训。

全世界都面临着 COVID-19 大流行的严峻挑战。为了遏制这种高度传染性疾病的传播，人们采取了一些短视的策略，如使用广谱抗生素和抗真菌药物。然而，抗生素的滥用和/或过度使用加剧了下一个流行病的出现：抗菌药耐药性（AMR）。据认为，病原体在人类和环境之间传播时，会携带来自不同物种的毒性和抗生素耐药性因子。据推测，所有这些遗传因子都是可以量化和预测的，更好地了解这些遗传因子可能会限制 AMR 的发展。在此，我们回顾了基于基因组学对 COVID-19 期间宿主与病原体相互作用的理解如何减少抗生素的非司法使用并防止未来爆发基于 AMR 的大流行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Briefings in Functional Genomics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-GENETICS & HEREDITY

CiteScore

6.30

自引率

2.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Briefings in Functional Genomics publishes high quality peer reviewed articles that focus on the use, development or exploitation of genomic approaches, and their application to all areas of biological research. As well as exploring thematic areas where these techniques and protocols are being used, articles review the impact that these approaches have had, or are likely to have, on their field. Subjects covered by the Journal include but are not restricted to: the identification and functional characterisation of coding and non-coding features in genomes, microarray technologies, gene expression profiling, next generation sequencing, pharmacogenomics, phenomics, SNP technologies, transgenic systems, mutation screens and genotyping. Articles range in scope and depth from the introductory level to specific details of protocols and analyses, encompassing bacterial, fungal, plant, animal and human data. The editorial board welcome the submission of review articles for publication. Essential criteria for the publication of papers is that they do not contain primary data, and that they are high quality, clearly written review articles which provide a balanced, highly informative and up to date perspective to researchers in the field of functional genomics.