Sarcoidosis and burn pit exposure in military deployers to Iraq, Afghanistan, and Southwest Asia.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-09-13 DOI:10.36141/svdld.v40i3.13956

Divya Patel, Johnny Jaber, Jennifer Loso, Hassan Perera, Salim Daouk, Ayoub Innabi, Diana Gomez-Manjarres, Silpa Krefft, Robert Miller

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Abstract

Background and aim: Inhalational exposures have been hypothesized to play a role in the pathogenesis of sarcoidosis. Herein, we describe a cohort of US Military personnel diagnosed with sarcoidosis during or after deployment to Southwest Asia and Afghanistan, who experienced complex inhalational exposures to burn-pits and desert dust.

Methods: Consecutive military personnel at four sub-specialty clinics across the United States were screened for deployment to Southwest Asia and Afghanistan and diagnosis of sarcoidosis based on 1999 ATS/ERS/WASOG Statement on Sarcoidosis. Detailed demographic, deployment and exposure data was collected. The data combined was analyzed after de-identification and local IRB approval.

Results: Twenty-one patients met our case definition. Seventeen patients were male and 62% had extrapulmonary involvement, including 38% with musculoskeletal involvement. Conclusions: Our study suggests that the sarcoidosis in military personnel to Southwest Asia can be diagnosed many years after deployment. To our knowledge, this is the first case series to describe a group of military personnel diagnosed with sarcoidosis and exposures specific to military deployment to Southwest Asia.

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伊拉克、阿富汗和西南亚军事部署人员的结节病和烧伤坑暴露。

背景和目的：假设吸入暴露在结节病的发病机制中发挥作用。在此，我们描述了一组在部署到西南亚和阿富汗期间或之后被诊断为结节病的美军人员，他们经历了燃烧坑和沙漠灰尘的复杂吸入暴露。方法：根据1999年ATS/ERS/WASOG关于结节病的声明，对美国四个分专科诊所的连续军事人员进行了部署到西南亚和阿富汗的筛查，并诊断为结节病。收集了详细的人口统计、部署和暴露数据。在取消识别和当地IRB批准后，对合并的数据进行分析。结果：21名患者符合我们的病例定义。17名患者为男性，62%为肺外受累，其中38%为肌肉骨骼受累。结论：我们的研究表明，西南亚军事人员的结节病可以在部署多年后诊断出来。据我们所知，这是第一个描述一组被诊断为结节病的军事人员以及在西南亚军事部署中暴露的病例系列。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.