MAGP1 maintains tumorigenicity and angiogenesis of laryngeal cancer by activating Wnt/β-catenin/MMP7 pathway.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-04-12 DOI:10.1093/carcin/bgad003

Fei Lv, Xiaoqi Li, Ying Wang, Liying Hao

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Abstract

Microfibril-associated glycoprotein-1 (MAGP1), a crucial extracellular matrix protein, contributes to the initiation and progression of different cancers. However, the role of MAGP1 in laryngeal cancer is not clear. The purpose of this study was to investigate the clinical significance and biological function of MAGP1 in laryngeal cancer. MAGP1 was upregulated in public databases and laryngeal cancer tissues, and high MAGP1 expression led to a poor prognosis and was identified as an independent prognostic marker. Knocking-down MAGP1 inhibited laryngeal cancer cell growth and metastasis. According to gene set enrichment analysis, high MAGP1 expression revealed enrichment in Wnt/β-catenin signaling and knocking-down MAGP1 in laryngeal cancer cells also caused degradation, de-activation, re-location and loss of stability of β-catenin. Additionally, we observed MAGP1 in laryngeal cancer cells inhibits angiogenesis in an MMP7-dependent way. In conclusion, our study suggests a clinical role of MAGP1 in laryngeal cancer, signifying its potential as a therapeutic target in the future.

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MAGP1 通过激活 Wnt/β-catenin/MMP7 通路维持喉癌的致瘤性和血管生成。

微纤维相关糖蛋白-1（MAGP1）是一种重要的细胞外基质蛋白，有助于不同癌症的发生和发展。然而，MAGP1在喉癌中的作用尚不明确。本研究旨在探讨MAGP1在喉癌中的临床意义和生物学功能。MAGP1在公共数据库和喉癌组织中上调，MAGP1的高表达导致预后不良，并被确定为独立的预后标志物。敲除 MAGP1 可抑制喉癌细胞的生长和转移。根据GSEA，MAGP1的高表达显示了Wnt/β-catenin信号转导的富集，在喉癌细胞中敲除MAGP1也会导致β-catenin降解、去激活、重新定位和失去稳定性。此外，我们还观察到喉癌细胞中的 MAGP1 以 MMP7 依赖性的方式抑制血管生成。总之，我们的研究表明了 MAGP1 在喉癌中的临床作用，标志着它有可能成为未来的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567