[NMDA receptors expression activity in anaplastic astrocytomas].

Q3 Medicine

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Pub Date : 2023-01-01 DOI:10.17116/jnevro202312301197

P V Nikitin, A Y Belyaev, G L Kobyakov, Y V Strunina, S V Shugay, G R Musina, D Y Usachev, P S Timashev

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引用次数: 0

Abstract

Objective: To study the relationship of NMDA receptors expression activity with proliferative activity and genetic properties of anaplastic astrocytomas, as well as the survival of patients with this disease.

Material and methods: To solve this problem, we compared the expression activity of the least studied NMDA receptors in the context under consideration, detected using immunofluorescent studies and polymerase chain reaction, with the results of histological and molecular studies, the proliferative activity of neoplasms, and the survival of patients.

Results: The expression activity of NMDA receptors is higher in astrocytomas, grade 3, which do not carry mutations in IDH1 and IDH2 genes. In addition, the activity of NMDA receptors expression directly correlates with proliferative activity in the tumors. The activity of NMDA receptor expression has a significant impact on the prognosis of disease-free survival.

Conclusion: We have shown for the first time the significant role of NMDA receptors in the progression of diffuse astrocytomas, which can become the basis for creating new therapeutic and diagnostic tools.

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NMDA受体在间变性星形细胞瘤中的表达活性。

目的:研究NMDA受体表达活性与间变性星形细胞瘤的增殖活性、遗传特性及患者生存率的关系。材料和方法:为了解决这一问题，我们将考虑的情况下研究最少的NMDA受体的表达活性，通过免疫荧光研究和聚合酶链反应检测，与组织学和分子研究结果，肿瘤的增殖活性和患者的生存进行了比较。结果:NMDA受体在3级星形细胞瘤中表达活性较高，不携带IDH1和IDH2基因突变。此外，NMDA受体的表达活性与肿瘤的增殖活性直接相关。NMDA受体的表达活性对无病生存的预后有重要影响。结论:我们首次揭示了NMDA受体在弥漫性星形细胞瘤进展中的重要作用，为开发新的治疗和诊断工具奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Medicine-Psychiatry and Mental Health

CiteScore

0.80

自引率

0.00%

发文量