Pharmacogenetic study of methadone treatment for heroin addiction: associations between drug-metabolizing gene polymorphisms and treatment efficacy.

IF 1.7 3区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Pharmacogenetics and genomics Pub Date : 2022-01-01 DOI:10.1097/FPC.0000000000000450

Yen-Jung Chen, Ju-Ting Lu, Chun-Wei Huang, Wei-Hsin Wu, Kuei-Fang Lee, Hsin-Tzu Liu, Lawrence Shih-Hsin Wu

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引用次数: 2

Abstract

Objectives: Opioid dependence is currently one of the most serious problems affecting the social norms and public health system. Methadone maintenance therapy (MMT) is being widely used in treating heroin-dependent patients. The mechanism of methadone metabolism and disposition has been shown to involve cytochrome P450 (CYP450) and P-glycoprotein. The aim of this study was to explore the relationships among genetic polymorphisms, BMI and effective dose of methadone used in MMT within a northern Taiwan cohort.

Methods: One hundred heroin-dependent patients were enrolled in the study. The clinical data gathered included methadone dose, sex and BMI. DNA was collected from the oral swab of the participants to analyze the relevant alleles.

Results: An effective methadone dose correlated with sex, BMI and the presence of ABCB1 2677GG (rs2032582) and CYP2B6 516GG (rs374527). Furthermore, the CYP2B6 516GG homozygote was related to a higher average dose of methadone (GG: 68.50 ± 32.43; GT: 52.28 ± 25.75; TT: 44.44 ± 29.64; P < 0.02), whereas the ABCB1 2677GG homozygote was related to a lower dose (GG: 51.09 ± 20.83; GT: 69.65 ± 37.51; TT: 62.52 ± 30.44; P < 0.05). We examined the predictive effect of polymorphisms combined with sex and BMI on methadone dose by conducting multiple linear regressions. Our data predicted the average dose of methadone in approximately 30% of heroin-dependent patients.

Conclusion: The interactions between genetic polymorphisms and clinical features proved useful in identifying the effective dose of MMT for heroin-dependent patients in Taiwan more precisely.

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美沙酮治疗海洛因成瘾的药物遗传学研究:药物代谢基因多态性与治疗效果的关系。

目的:阿片类药物依赖是目前影响社会规范和公共卫生系统的最严重问题之一。美沙酮维持疗法(MMT)被广泛应用于海洛因依赖患者的治疗。美沙酮代谢和处置的机制已被证明涉及细胞色素P450 (CYP450)和p糖蛋白。摘要本研究旨在探讨台湾北部人群在MMT治疗中，遗传多态性、BMI与美沙酮有效剂量之间的关系。方法:选取100例海洛因依赖患者作为研究对象。收集的临床数据包括美沙酮剂量、性别和身体质量指数。从参与者的口腔拭子中收集DNA以分析相关等位基因。结果:美沙酮有效剂量与性别、BMI、ABCB1 2677GG (rs2032582)和CYP2B6 516GG (rs374527)存在相关。此外，CYP2B6 516GG纯合子与较高的平均美沙酮剂量相关(GG: 68.50±32.43;Gt: 52.28±25.75;Tt: 44.44±29.64;P < 0.02)，而ABCB1 2677GG纯合子与低剂量相关(GG: 51.09±20.83;Gt: 69.65±37.51;Tt: 62.52±30.44;P < 0.05)。我们通过多元线性回归检验了多态性、性别和BMI对美沙酮剂量的预测作用。我们的数据预测了大约30%的海洛因依赖患者的平均剂量美沙酮。结论:遗传多态性与临床特征之间的相互作用有助于更准确地确定台湾海洛因依赖患者MMT的有效剂量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacogenetics and genomics 医学-生物工程与应用微生物

CiteScore

3.20

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Pharmacogenetics and Genomics is devoted to the rapid publication of research papers, brief review articles and short communications on genetic determinants in response to drugs and other chemicals in humans and animals. The Journal brings together papers from the entire spectrum of biomedical research and science, including biochemistry, bioinformatics, clinical pharmacology, clinical pharmacy, epidemiology, genetics, genomics, molecular biology, pharmacology, pharmaceutical sciences, and toxicology. Under a single cover, the Journal provides a forum for all aspects of the genetics and genomics of host response to exogenous chemicals: from the gene to the clinic.