Comparing Longitudinal Measures of Cholinesterase as Biomarkers for Insecticide Exposure Among Latinx Children in Rural Farmworker and Urban Nonfarmworker Communities in North Carolina.

IF 2.3 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Occupational and Environmental Medicine Pub Date : 2023-12-01 Epub Date: 2023-09-06 DOI:10.1097/JOM.0000000000002965

Sara A Quandt, Sydney A Smith, Thomas A Arcury, Haiying Chen, Kirstin Hester, Carey N Pope, Kim A Anderson, Paul J Laurienti

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Abstract

Objective: In a 2-group prospective design, this study compared seasonal cholinesterase levels of Latinx children in rural farmworker families and comparable urban children to assess the impact of environmental exposure to cholinesterase-inhibiting insecticides.

Methods: Quarterly blood samples and passive dosimeter wristbands were collected over 2 years in 8-year-old children (74 rural, 62 urban). Laboratory analysis assessed total cholinesterase, acetylcholinesterase, and butyrylcholinesterase from blood samples, and insecticides from wristbands.

Results: In spring and summer, total cholinesterase and acetylcholinesterase levels were depressed in rural children compared with winter and fall. Butyrylcholinesterase was depressed in rural children in fall compared with spring and summer. Adjustment for insecticide exposure did not affect these associations.

Conclusions: Environmental exposures to cholinesterase-inhibiting insecticides have measurable biochemical effects on blood cholinesterases in rural children from farmworker families.

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比较北卡罗来纳州农村农场工人和城市非农场工人社区拉丁裔儿童胆碱酯酶作为杀虫剂暴露生物标志物的纵向测量。

目的：在两组前瞻性设计中，本研究比较了农村农场工人家庭中拉丁裔儿童和可比城市儿童的季节性胆碱酯酶水平，以评估环境暴露于胆碱酯酶抑制杀虫剂的影响。方法：每季度采集8岁儿童（74名农村儿童，62名城市儿童）2年以上的血液样本和被动剂量计腕带。实验室分析评估了血液样本中的总胆碱酯酶（total ChE）、乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE），以及腕带中的杀虫剂。结果：与冬季和秋季相比，春季和夏季农村儿童的总ChE和AChE水平下降。与春季和夏季相比，秋季农村儿童的BChE较低。杀虫剂暴露量的调整并没有影响这些关联。结论：环境暴露于胆碱酯酶抑制剂对来自农场工人家庭的农村儿童的血胆碱酯酶具有可测量的生化影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Occupational and Environmental Medicine 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.20

自引率

9.40%

发文量

402

审稿时长

3-8 weeks

期刊介绍： Journal of Occupational and Environmental Medicine is an indispensable guide to good health in the workplace for physicians, nurses, and researchers alike. In-depth, clinically oriented research articles and technical reports keep occupational and environmental medicine specialists up-to-date on new medical developments in the prevention, diagnosis, and rehabilitation of environmentally induced conditions and work-related injuries and illnesses.