Dual organ transplantation: when heart alone is not enough.

IF 1.8 4区医学 Q3 TRANSPLANTATION

Current Opinion in Organ Transplantation Pub Date : 2023-10-01 Epub Date: 2023-08-13 DOI:10.1097/MOT.0000000000001093

Abdulelah Nuqali, Lavanya Bellumkonda

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引用次数: 0

Abstract

Purpose of review: The number of dual organ transplantations (DOT) are steadily increasing over the past few years. This is both a reflection of increasing complexity and advanced disease process in the patients and greater transplant center experience with performing dual organ transplants. Due to lack of standardization of the process, there remains significant center-based variability in patient selection, perioperative and long-term management of these patients.

Recent findings: Overall posttransplant outcomes for DOT have been acceptable with some immunological advantages because of partial tolerance offered by the second organ. These achievements should, however, be balanced with the ethical implications of bypassing the patients who are listed for single organ transplantation because of the preferential allocation of organs for DOT.

Summary: The field of DOT is expanding rapidly, with good long-term outcomes. There is an urgent need for guidelines to standardize the process of patient selection and listing dual organ transplantation.

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双器官移植：当心脏是不够的。

综述目的：在过去几年中，双器官移植（DOT）的数量稳步增加。这既反映了患者日益复杂和晚期的疾病过程，也反映了移植中心在进行双器官移植方面的更多经验。由于流程缺乏标准化，在患者选择、围手术期和这些患者的长期管理方面，仍存在显著的基于中心的变异性。最近的发现：由于第二器官提供的部分耐受性，DOT的总体移植后结果是可以接受的，具有一些免疫学优势。然而，这些成就应该与绕过因DOT优先分配器官而被列入单器官移植名单的患者的伦理影响相平衡。总结：DOT领域正在迅速扩张，并取得了良好的长期结果。迫切需要制定指导方针，以规范双器官移植的患者选择和上市过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Organ Transplantation 医学-移植

CiteScore

4.10

自引率

4.50%

发文量

124

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.