Effect of Temperature and Humidity on the Allegro-inflammatory Factors and Allergic Rhinitis-related Behavior.

IF 1.2 4区 医学 Q4 ALLERGY
Shen Yonghua, Entezar Mehrabi Nasab, Yen Liuo
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引用次数: 0

Abstract

Allergic rhinitis (AR) is an allergic disease induced by the T helper 2 (TH2) lymphocyte immune response, where its mediators are the primary cause of clinical symptoms. Environmental factors are the primary determinants of the allergic response in genetically susceptible individuals. This study investigates the effects of climate conditions (warm, cold, humid, and dry) on allergic rhinitis. AR models were created in mice under 4 different conditions. We investigated AR-related behavior (sneezing and nose rubbing), as well as total immunoglobulin E (IgE), histamine, interleukin-4 (IL-4), leukotriene (LT) B4 and LTC4 levels, and gene expression of CysLT1R, HRH1, and MUC5a. Nose rubbing, histamine levels, and the expression of MUC5a and HRH1 were increased in AR models in cold conditions, and sneezing was increased in AR models kept in dry conditions. LTB4 and LTC4 levels and the expression of CysLT1R in AR models kept in a wet environment also significantly increased compared with the control group. The levels of total IgE and IL-4 showed no significant changes. Air temperature and humidity affect AR pathophysiology, and weather conditions can be essential in controlling AR.

温度和湿度对过敏性鼻炎相关行为及致敏性炎症因子的影响。
变应性鼻炎(AR)是一种由辅助性T细胞2 (TH2)免疫反应引起的变应性疾病,其介质是临床症状的主要原因。环境因素是遗传易感个体过敏反应的主要决定因素。本研究探讨气候条件(温暖、寒冷、潮湿和干燥)对变应性鼻炎的影响。在4种不同条件下建立小鼠AR模型。我们调查了ar相关行为(打喷嚏和摩擦鼻子),以及总免疫球蛋白E (IgE)、组胺、白细胞介素4 (IL-4)、白三烯(LT) B4和LTC4水平,以及cysllt1r、HRH1和MUC5a的基因表达。在寒冷条件下,AR模型的鼻摩擦、组胺水平以及MUC5a和HRH1的表达增加,在干燥条件下,AR模型的打喷嚏增加。湿润环境下的AR模型LTB4、LTC4水平及cysllt1r表达也较对照组显著升高。总IgE和IL-4水平无明显变化。空气温度和湿度影响AR的病理生理,天气条件对AR的控制至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.60
自引率
6.70%
发文量
64
审稿时长
>12 weeks
期刊介绍: The Iranian Journal of Allergy, Asthma and Immunology (IJAAI), an international peer-reviewed scientific and research journal, seeks to publish original papers, selected review articles, case-based reviews, and other articles of special interest related to the fields of asthma, allergy and immunology. The journal is an official publication of the Iranian Society of Asthma and Allergy (ISAA), which is supported by the Immunology, Asthma and Allergy Research Institute (IAARI) and published by Tehran University of Medical Sciences (TUMS). The journal seeks to provide its readers with the highest quality materials published through a process of careful peer reviews and editorial comments. All papers are published in English.
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