Pharmacogenetic impact of SLC22A1 gene variant rs628031 (G/A) in newly diagnosed Indian type 2 diabetes patients undergoing metformin monotherapy.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-04-01 DOI:10.1097/FPC.0000000000000493

Shalini Singh, Ashwin Kumar Shukla, Kauser Usman, Monisha Banerjee

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引用次数: 1

Abstract

Objectives: Type 2 diabetes (T2D) imposes an enormous burden all over the world in both developed and developing countries. Inter-individual differences are attributed to polymorphisms in candidate genes resulting in altered absorption, transportation, distribution, and metabolism of oral antidiabetic drugs (OADs). Hence, the present study was undertaken to evaluate the pharmacogenetic impact of SLC22A1 gene variant rs628031 (G/A) on metformin monotherapy in newly diagnosed untreated T2D patients.

Methods: Newly diagnosed T2D patients ( n = 500) were enrolled according to inclusion/exclusion criteria. Initially, enrolled subjects were prescribed metformin monotherapy and followed up for at least 12 weeks. Response to metformin was evaluated in 478 patients who revisited for follow-up by measuring HbA1c.

Result: Out of 478 patients, 373 were responders to metformin monotherapy while 105 were non-responders. The pharmacogenetic impact was evaluated by genotype, haplotype, and pharmacogenetic analyses. 'GG' genotype and 'G' allele of SLC22A1 rs628031 G/A were observed in 48.8% and 67.7% of Met responders, respectively, while 20.9% and 49.1 % were in non-responders. Therefore, there was a 2.18-fold increase in the success rate of Met therapeutics.

Conclusion: Individuals carrying the 'GG' genotype or 'G' allele for SLC22A1 gene variant rs628031 G/A are better responders for Metformin monotherapy.

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SLC22A1基因变异rs628031 (G/A)对接受二甲双胍单药治疗的新诊断印度2型糖尿病患者的药理学影响

目的:2型糖尿病(T2D)在全世界发达国家和发展中国家都是一个巨大的负担。个体间差异归因于候选基因的多态性，导致口服降糖药(oad)的吸收、运输、分布和代谢发生改变。因此，本研究旨在评估SLC22A1基因变异rs628031 (G/A)对新诊断未经治疗的T2D患者二甲双胍单药治疗的药理学影响。方法:根据纳入/排除标准纳入新诊断的T2D患者500例。最初，受试者接受二甲双胍单药治疗，随访至少12周。通过测量HbA1c来评估478名患者对二甲双胍的反应。结果:478例患者中，373例对二甲双胍单药治疗有反应，105例无反应。通过基因型、单倍型和药物遗传分析来评估药物遗传影响。SLC22A1 rs628031 G/A“GG”基因型和“G”等位基因在Met应答者中分别占48.8%和67.7%，而在无应答者中分别占20.9%和49.1%。因此，Met疗法的成功率增加了2.18倍。结论:携带SLC22A1基因变异rs628031 G/A“GG”基因型或“G”等位基因的个体对二甲双胍单药治疗的反应更好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.