Adipose-Derived Stromal/Stem Cell Response to Tumors and Wounds: Evaluation of Patient Age.

IF 2.5 3区医学 Q3 CELL & TISSUE ENGINEERING

Stem cells and development Pub Date : 2022-10-01 Epub Date: 2022-05-16 DOI:10.1089/scd.2021.0280

Katie M Hamel, Kara Q Liimatta, Jorge A Belgodere, Bruce A Bunnell, Jeffrey M Gimble, Elizabeth C Martin

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引用次数: 2

Abstract

Tumors were characterized as nonhealing wounds by Virchow in 1858 and Dvorak in 1986. Since then, researchers have analyzed tumors from a new perspective. The parallels between tumorigenesis and physiological wound healing can provide a new framework for developing antitumor therapeutics. One commonality between tumors and wounds is the involvement of the stromal environment, particularly adipose stromal/stem cells (ASCs). ASCs exhibit dual functions, in which they stimulate tumor progression and assist in tissue repair and regeneration. Numerous studies have focused on the role of ASCs in cancer and wound healing, but none to date has linked age, cancer, and wound healing. Furthermore, very few studies have focused on the role of donor-specific characteristics of ASCs, such as age and their role in facilitating ASC behavior in cancer and wound healing. This review article is designed to provide important insights into the impact of donor age on ASC tumor and wound response and their role in facilitating ASC behavior in cancer and wound healing.

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脂肪来源的基质/干细胞对肿瘤和伤口的反应：患者年龄的评估。

Virchow在1858年和Dvorak在1986年将肿瘤描述为无法愈合的伤口。从那时起，研究人员从一个新的角度分析肿瘤。肿瘤发生和生理伤口愈合之间的相似性可以为开发抗肿瘤疗法提供新的框架。肿瘤和伤口之间的一个共同点是基质环境的参与，特别是脂肪基质/干细胞（ASCs）。ASCs表现出双重功能，其中它们刺激肿瘤进展并帮助组织修复和再生。许多研究关注ASCs在癌症和伤口愈合中的作用，但迄今为止没有一项研究将年龄、癌症和伤口愈合联系起来。此外，很少有研究关注ASCs的供体特异性特征的作用，如年龄及其在促进ASCs在癌症和伤口愈合中的行为中的作用。这篇综述文章旨在提供重要的见解，了解供体年龄对ASC肿瘤和伤口反应的影响，以及它们在促进癌症和伤口愈合中的ASC行为中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem cells and development 医学-细胞与组织工程

CiteScore

7.80

自引率

2.50%

发文量

审稿时长

3 months

期刊介绍： Stem Cells and Development is globally recognized as the trusted source for critical, even controversial coverage of emerging hypotheses and novel findings. With a focus on stem cells of all tissue types and their potential therapeutic applications, the Journal provides clinical, basic, and translational scientists with cutting-edge research and findings. Stem Cells and Development coverage includes: Embryogenesis and adult counterparts of this process Physical processes linking stem cells, primary cell function, and structural development Hypotheses exploring the relationship between genotype and phenotype Development of vasculature, CNS, and other germ layer development and defects Pluripotentiality of embryonic and somatic stem cells The role of genetic and epigenetic factors in development

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