Renal agenesis: A meta-analysis of its prevalence and clinical characteristics based on 15 641 184 patients.

IF 2.4 4区医学 Q2 UROLOGY & NEPHROLOGY

Nephrology Pub Date : 2023-10-01 DOI:10.1111/nep.14190

Dawid Plutecki, Tomasz Kozioł, Michał Bonczar, Patryk Ostrowski, Alicja Skorupa, Szymon Matejuk, Jerzy Walocha, Jakub Pękala, Agata Musiał, Artur Pasternak, Mateusz Koziej

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引用次数: 0

Abstract

Our objective was to analyse the newest relevant data on worldwide prevalence and associated symptoms of renal agenesis (RA). This meta‐analysis builds on previous systematic reviews to include bilateral RA, its symptoms and data on gender, unilateral RA and anomaly location prevalence. Review of available data included records in English and other languages from PubMed, Embase, ScienceDirect, Web of Science, SciELO, BIOSIS, Current Content Connect Korean Journal Database and Russian Citation Index and Google. A total of 15 641 184 patients were analysed in relation to the prevalence of RA. The pooled prevalence of RA was 0.03% (95% CI: 0.03%–0.04%). Based on 500 subjects, a pooled prevalence of 47.96% (95% CI: 31.55%–64.58%) for unilateral and 52.04% (95% CI: 35.42%–68.45%) for bilateral RA has been set. Our study presents the newest generalized findings on bilateral RA. There appears to be universal disease and symptom prevalence with minor differences between world regions, although quality of future observational research should include genomic data. This will provide even further insight into the prognosis of various renal anomalies and their etiologies.

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肾发育不全：基于15例的发病率和临床特征的荟萃分析 641 184名患者。

我们的目的是分析世界范围内肾发育不全（RA）患病率和相关症状的最新相关数据。这项荟萃分析建立在先前的系统综述的基础上，包括双侧RA、其症状和性别、单侧RA和异常位置患病率的数据。对可用数据的审查包括PubMed、Embase、ScienceDirect、Web of Science、SciELO、BIOSIS、Current Content Connect韩国期刊数据库、俄罗斯引文索引和谷歌的英文和其他语言记录。共15个 641 对184例患者进行了RA患病率分析。RA的合并患病率为0.03%（95%CI:0.03%-0.04%）。基于500名受试者，单侧RA的合并发病率为47.96%（95%CI:31.55%-64.58%），双侧RA的合并流行率为52.04%（95%CI:35.42%-68.45%）。我们的研究提出了关于双侧RA的最新的一般性发现。尽管未来观察性研究的质量应包括基因组数据，但世界各地区的疾病和症状流行率似乎普遍存在，差异较小。这将进一步深入了解各种肾脏异常的预后及其病因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nephrology 医学-泌尿学与肾脏学

CiteScore

4.50

自引率

4.00%

发文量

128

审稿时长

4-8 weeks

期刊介绍： Nephrology is published eight times per year by the Asian Pacific Society of Nephrology. It has a special emphasis on the needs of Clinical Nephrologists and those in developing countries. The journal publishes reviews and papers of international interest describing original research concerned with clinical and experimental aspects of nephrology.