Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.

IF 3.9 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Expert Opinion on Drug Metabolism & Toxicology Pub Date : 2022-11-01 DOI:10.1080/17425255.2022.2151893

Slobodan M Janković

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引用次数: 3

Abstract

Introduction: Although N-acetyl-cysteine (NAC) has long been used for the treatment of acetaminophen poisoning/overdose, the optimal NAC dosing regimen for varying patterns or severity of the poisoning/overdose is still unknown.

Areas covered: Relevant literature was searched for in the MEDLINE (from 1964 until August 31^st, 2022), SCOPUS (from 2004 until August 31^st, 2022) and GOOGLE SCHOLAR (from 2004 until August 31^st, 2022) databases, without restriction in terms of publication date. The inclusion criteria were: original clinical studies reporting results, and studies investigating efficacy and safety of NAC dosing regimens in case(s) of overdose or poisoning with acetaminophen.

Expert opinion: For a more effective treatment of acetaminophen poisoning in the future, it will be crucial to advance the technology of measuring acetaminophen, its metabolites and NAC in the serum, preferably with the point-of-care technique, so that in real time it can be continuously assessed whether it is necessary to administer NAC, and further to increase the dose of NAC and extend the duration of its administration, or not.

查看原文本刊更多论文

对乙酰氨基酚的毒性和过量:NAC给药方案的当前认识和未来方向。

虽然n -乙酰半胱氨酸(NAC)长期以来一直用于治疗对乙酰氨基酚中毒/过量，但对于不同模式或严重程度的中毒/过量，NAC的最佳给药方案仍然未知。涉及领域:检索MEDLINE(1964年至2022年8月31日)、SCOPUS(2004年至2022年8月31日)和GOOGLE SCHOLAR(2004年至2022年8月31日)数据库的相关文献，不受发表日期限制。纳入标准为:报告结果的原始临床研究，以及调查对乙酰氨基酚过量或中毒情况下NAC给药方案的有效性和安全性的研究。专家意见:为了今后更有效地治疗对乙酰氨基酚中毒，改进血清中对乙酰氨基酚及其代谢物和NAC的检测技术，最好采用即时护理技术，实时连续评估是否需要给药，进而增加NAC的剂量和延长给药时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Opinion on Drug Metabolism & Toxicology 医学-生化与分子生物学

CiteScore

7.90

自引率

2.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Expert Opinion on Drug Metabolism & Toxicology (ISSN 1742-5255 [print], 1744-7607 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on all aspects of ADME-Tox. Each article is structured to incorporate the author’s own expert opinion on the scope for future development. The Editors welcome: Reviews covering metabolic, pharmacokinetic and toxicological issues relating to specific drugs, drug-drug interactions, drug classes or their use in specific populations; issues relating to enzymes involved in the metabolism, disposition and excretion of drugs; techniques involved in the study of drug metabolism and toxicology; novel technologies for obtaining ADME-Tox data. Drug Evaluations reviewing the clinical, toxicological and pharmacokinetic data on a particular drug. The audience consists of scientists and managers in the pharmaceutical industry, pharmacologists, clinical toxicologists and related professionals.