CYBA as a Potential Biomarker for Renal Cell Carcinoma: Evidence from an Integrated Genetic Analysis.

IF 2.6 4区医学 Q2 GENETICS & HEREDITY

Cancer Genomics & Proteomics Pub Date : 2023-09-01 DOI:10.21873/cgp.20398

Chi-Fen Chang, Shu-Pin Huang, Yu-Mei Hsueh, Pei-Ling Chen, Cheng-Hsueh Lee, Jiun-Hung Geng, Chao-Yuan Huang, Bo-Ying Bao

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引用次数: 0

Abstract

Background/aim: Oxidative stress plays an important role in various pathogenic processes, and disruption in the coordinated production of NADPH oxidase (NOX)-derived reactive oxygen species has been associated with carcinogenesis. However, little is known about whether genetic variants in NOX can contribute to the development of renal cell carcinoma (RCC).

Patients and methods: This study aimed to bridge this knowledge gap by analysing the association of 10 single-nucleotide polymorphisms in the phagocyte NOX genes, CYBA and CYBB, with RCC risk and tumour characteristics in 630 RCC patients and controls. Differential gene expression and patient prognosis analyses were performed using gene expression data obtained from public databases.

Results: Multivariate analysis and multiple testing corrections revealed the A allele of rs7195830 in CYBA to be a significant risk allele for RCC, compared to the G allele [odds ratio (OR)=1.70, 95% confidence interval (CI)=1.27-2.26, p<0.001]. A pooled analysis of 17 renal cancer gene expression datasets revealed a higher CYBA expression in RCC than in normal tissues. Moreover, high CYBA expression was associated with advanced tumour characteristics and worse patient prognosis.

Conclusion: CYBA might play an oncogenic role in RCC and serve as a predictive indicator of patient prognosis.

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CYBA作为肾细胞癌的潜在生物标志物：来自综合遗传分析的证据。

背景/目的：氧化应激在各种致病过程中起着重要作用，NADPH氧化酶（NOX）衍生的活性氧的协同产生被破坏与致癌有关。然而，人们对NOX的基因变异是否会导致肾细胞癌（RCC）的发展知之甚少。患者和方法：本研究旨在通过分析吞噬细胞NOX基因CYBA和CYBB的10个单核苷酸多态性与630名肾细胞癌患者和对照组的RCC风险和肿瘤特征的关系，弥合这一知识差距。使用从公共数据库获得的基因表达数据进行差异基因表达和患者预后分析。结果：多因素分析和多重检测校正显示，与G等位基因相比，CYBA中rs7195830的A等位基因是RCC的显著危险等位基因[比值比（OR）=1.70，95%置信区间（CI）=1.27-2.26，P结论：CYBA可能在RCC中起致癌作用，并可作为患者预后的预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Genomics & Proteomics ONCOLOGY-GENETICS & HEREDITY

CiteScore

5.00

自引率

8.00%

发文量

期刊介绍： Cancer Genomics & Proteomics (CGP) is an international peer-reviewed journal designed to publish rapidly high quality articles and reviews on the application of genomic and proteomic technology to basic, experimental and clinical cancer research. In this site you may find information concerning the editorial board, editorial policy, issue contents, subscriptions, submission of manuscripts and advertising. The first issue of CGP circulated in January 2004. Cancer Genomics & Proteomics is a journal of the International Institute of Anticancer Research. From January 2013 CGP is converted to an online-only open access journal. Cancer Genomics & Proteomics supports (a) the aims and the research projects of the INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH and (b) the organization of the INTERNATIONAL CONFERENCES OF ANTICANCER RESEARCH.