Hepatitis C Seroconversion Remains High among Patients with Regular Hemodialysis: Study of Associated Risk Factors.

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY

International Journal of Hepatology Pub Date : 2022-12-29 eCollection Date: 2022-01-01 DOI:10.1155/2022/8109977

Ni Wayan Wina Dharmesti, I Dewa Nyoman Wibawa, Yenny Kandarini

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引用次数: 0

Abstract

Methods: An analytical cross-sectional study involving patients from 2 dialysis units (1 referral hospital and 1 private dialysis unit) in Denpasar, Bali, Indonesia, from January 2020 to December 2021. We evaluated age, gender, duration of hemodialysis, vascular access, history of transfusion, history of surgery, diabetes mellitus, hepatitis B, human immunodeficiency virus (HIV) infection, and type of dialyzer as possible risk factors of hepatitis C seroconversion among hemodialysis patients.

Results: A total of 338 hemodialysis patients were enrolled in this study. We found hepatitis C seroconversion in 94 patients (27.8%), all of which occurred after regular dialysis was started. Vascular access type (OR 42.07, 95% CI 5.757-307.472) and dialyzer reuse (OR 8.324, 95% CI 4.319-16.044) were showing a statistically significant association with hepatitis C seroconversion. A separate analysis on each dialysis unit found common evidence that the duration of dialysis was significantly associated with hepatitis C infection among hemodialysis patients.

Conclusion: Hepatitis C seroconversion among dialysis patients remains high. Factors related to the dialysis procedure itself played a major role in transmitting the virus.

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定期血液透析患者中丙型肝炎血清转换率仍然很高：相关风险因素研究。

研究方法：这是一项横断面分析研究，涉及印度尼西亚巴厘岛登巴萨市 2 家透析单位（1 家转诊医院和 1 家私营透析单位）的患者，研究时间为 2020 年 1 月至 2021 年 12 月。我们对血液透析患者的年龄、性别、血液透析时间、血管通路、输血史、手术史、糖尿病、乙型肝炎、人类免疫缺陷病毒（HIV）感染和透析器类型等丙型肝炎血清转换的可能风险因素进行了评估：本研究共招募了 338 名血液透析患者。我们发现有 94 名患者（27.8%）发生了丙型肝炎血清转换，这些患者都是在开始定期透析后发生的。血管通路类型（OR 42.07，95% CI 5.757-307.472）和透析器重复使用（OR 8.324，95% CI 4.319-16.044）与丙型肝炎血清转换有显著的统计学关联。对每个透析单位进行的单独分析发现，有共同证据表明透析持续时间与血液透析患者的丙型肝炎感染显著相关：结论：透析患者中的丙型肝炎血清转换率仍然很高。与透析过程本身有关的因素在传播病毒方面发挥了重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： International Journal of Hepatology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the medical, surgical, pathological, biochemical, and physiological aspects of hepatology, as well as the management of disorders affecting the liver, gallbladder, biliary tree, and pancreas.