Occurrence and associated health risks of pyrrolizidine alkaloids in supplements marketed in Ghana for improved sexual performance.

IF 2.5 3区农林科学 Q2 CHEMISTRY, APPLIED

Food additives & contaminants. Part B, Surveillance Pub Date : 2023-09-01 DOI:10.1080/19393210.2023.2227961

Felicia Akuamoa, Patrick P J Mulder, Toine F H Bovee, Ivonne M C M Rietjens, Ron L A P Hoogenboom

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引用次数: 1

Abstract

Pyrrolizidine alkaloids (PAs) are noted for their hepatotoxic, genotoxic, and carcinogenic effects in animals and humans following metabolic activation in the liver. In this study, herbal supplements sold in Ghana for sexual improvement were analysed for the presence of 64 PAs using LC-MS/MS analysis. Up to 17 different PAs were identified in 19 out of the 37 samples analysed. The sum of PAs in samples ranged from 5 to 3204 μg kg^-1. Since the PA content in the herbal medicinal preparations was generally lower than in honey samples, their presence was mainly attributed to cross-contamination. The observed levels would result in estimated daily intakes from 0.01 to 12 μg per day or 0.0002 to 0.2 μg kg^-1 bw day^-1 for a person weighing 70 kg. The margins of exposure ranged from 1200 to 1,400,000 with eight samples showing values below 10,000, thus indicating a health concern.

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在加纳销售的用于改善性行为的补充剂中出现吡咯利西啶生物碱及其相关的健康风险。

吡咯利西啶生物碱(PAs)在肝脏代谢激活后对动物和人类具有肝毒性、遗传毒性和致癌作用。在这项研究中，使用LC-MS/MS分析了在加纳销售的用于改善性功能的草药补充剂中64个PAs的存在。在分析的37个样本中，有19个样本鉴定出了多达17种不同的PAs。样品中PAs含量为5 ~ 3204 μg kg-1。由于草药制剂中的PA含量普遍低于蜂蜜样品，因此它们的存在主要归因于交叉污染。观察到的水平将导致每日摄入量估计为每天0.01至12 μg，或体重70公斤的人每天0.0002至0.2 μg kg-1磅。接触范围从1200至140万，其中8个样本的值低于1万，这表明存在健康问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food additives & contaminants. Part B, Surveillance 农林科学-毒理学

CiteScore

5.30

自引率

10.30%

发文量

审稿时长

2.7 months

期刊介绍： Food Additives & Contaminants: Part B publishes surveillance data indicating the presence and levels of occurrence of designated food additives, residues and contaminants in foods, food supplements and animal feed. Data using validated methods must meet stipulated quality standards to be acceptable and must be presented in a prescribed format for subsequent data-handling. Food Additives & Contaminants: Part B restricts its scope to include certain classes of food additives, residues and contaminants. This is based on a goal of covering those areas where there is a need to record surveillance data for the purposes of exposure and risk assessment. The scope is initially restricted to: Additives - food colours, artificial sweeteners, and preservatives; Residues – veterinary drug and pesticide residues; Contaminants – metals, mycotoxins, phycotoxins, plant toxins, nitrate/nitrite, PCDDs/PCFDs, PCBs, PAHs, acrylamide, 3-MPCD and contaminants derived from food packaging. Readership: The readership includes scientists involved in all aspects of food safety and quality and particularly those involved in monitoring human exposure to chemicals from the diet. Papers reporting surveillance data in areas other than the above should be submitted to Part A . The scope of Part B will be expanded from time-to-time to ensure inclusion of new areas of concern.