Congenital cytomegalovirus infection with brainstem hemorrhage and polymicrogyria: Necropsic and histopathological findings

IF 1.3 4区 医学 Q3 PEDIATRICS
Javier Arredondo Montero, Mónica Bronte Anaut, María Cristina Caballero Martínez, Maria Pilar Fernández Seara, Nerea Martín-Calvo
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引用次数: 0

Abstract

Congenital cytomegalovirus (CMV) infection can cause severe neurological sequelae or even fetal death. We present a 17-year-old pregnant woman with fetal CMV infection, leading to voluntary termination of pregnancy. Fetopsy demonstrated a brainstem hemorrhage and focal polymicrogyria. CMV inclusions were observed in the lung, liver, thyroid, pancreas, kidneys, adrenal, placenta, and central nervous system. Intracranial hemorrhage is a rare finding in the context of congenital CMV infection, with isolated brainstem hemorrhage being an exceptional form of presentation. Polymicrogyria appears to be a more frequent finding, although its actual incidence is unknown. Future studies are needed to determine the causal association.

Abstract Image

先天性巨细胞病毒感染合并脑干出血和多小回畸形:坏死和组织病理学结果
先天性巨细胞病毒(CMV)感染可引起严重的神经系统后遗症甚至胎儿死亡。我们提出一个17岁的孕妇与胎儿巨细胞病毒感染,导致自愿终止妊娠。尸检显示脑干出血和局灶性多小回畸形。在肺、肝、甲状腺、胰腺、肾脏、肾上腺、胎盘和中枢神经系统均可见巨细胞病毒包体。颅内出血是先天性巨细胞病毒感染的一种罕见的发现,孤立的脑干出血是一种特殊的表现形式。多小回症似乎是一种更常见的发现,尽管其实际发病率尚不清楚。未来的研究需要确定因果关系。
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来源期刊
Congenital Anomalies
Congenital Anomalies PEDIATRICS-
自引率
0.00%
发文量
49
审稿时长
>12 weeks
期刊介绍: Congenital Anomalies is the official English language journal of the Japanese Teratology Society, and publishes original articles in laboratory as well as clinical research in all areas of abnormal development and related fields, from all over the world. Although contributions by members of the teratology societies affiliated with The International Federation of Teratology Societies are given priority, contributions from non-members are welcomed.
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