[Time-restricted eating as a novel strategy for treatment of obesity and it's comorbid conditions].

Q4 Medicine
M A Berkovskaya, O Y Gurova, I A Khaykina, V V Fadeev
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引用次数: 0

Abstract

The article provides a review of the current literature about time-restricted eating (TRE) as a new tool for the treatment of obesity and comorbid conditions. The search for new nutritional strategies in obesity, one of which is TRE, is due to the weak adherence of patients to hypocaloric diets in the long term, as well as the available data on the importance of -desynchronization of food intake with natural circadian rhythms in the development and progression of obesity and cardio--metabolic complications. The article describes the main mechanisms that regulate the circadian rhythms of food intake and nutrient absorption, substantiates the importance of adhering to a physiological diet for maintaining metabolic health. The main part of the review is devoted to reviewing the currently available researches on the effectiveness of various strategies of intermittent energy restriction for weight loss and the correction of metabolic parameters. Potential mechanisms of  the -effect of TRE on health are discussed, including those mediated by an unintentional decrease in caloric intake and changes in eating behavior, and differences in the effectiveness of early and late TRE. The article contains a detailed discussion of the potential problems and contradictions associated with the use of time-restricted eating in clinical practice, namely: the limitations and inconsistencies of the available clinical trials, the lack of data on long-term efficacy and safety, social and psychological limitations that impede the widespread use of TRE.

[限时饮食作为治疗肥胖及其并发症的新策略]。
本文综述了目前关于限时饮食(TRE)作为治疗肥胖和合并症的新工具的文献。寻找新的肥胖营养策略,其中之一是TRE,是由于患者长期坚持低热量饮食的能力较弱,以及现有数据表明食物摄入与自然昼夜节律不同步在肥胖和心脏代谢并发症的发生和进展中的重要性。本文描述了调节食物摄入和营养吸收昼夜节律的主要机制,证实了坚持生理饮食对维持代谢健康的重要性。综述的主要部分是对目前关于各种间歇性能量限制策略对减肥和代谢参数校正的有效性的研究进行综述。本文还讨论了三次营养刺激对健康影响的潜在机制,包括由热量摄入的无意减少和饮食行为的改变所介导的机制,以及早期和晚期三次营养刺激有效性的差异。这篇文章详细讨论了在临床实践中使用限时饮食相关的潜在问题和矛盾,即:现有临床试验的局限性和不一致性,缺乏长期疗效和安全性的数据,阻碍TRE广泛使用的社会和心理限制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Problemy endokrinologii
Problemy endokrinologii Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
1.40
自引率
0.00%
发文量
59
期刊介绍: Since 1955 the “Problems of Endocrinology” (or “Problemy Endocrinologii”) Journal publishes timely articles, balancing both clinical and experimental research, case reports, reviews and lectures on pressing problems of endocrinology. The Journal is aimed to the most topical issues of endocrinology: to chemical structure, biosynthesis and metabolism of hormones, the mechanism of their action at cellular and molecular level; pathogenesis and to clinic of the endocrine diseases, new methods of their diagnostics and treatment. The Journal: features original national and foreign research articles, reflecting world endocrinology development; issues thematic editions on specific areas; publishes chronicle of major international congress sessions and workshops on endocrinology, as well as state-of-the-art guidelines; is intended for scientists, endocrinologists diabetologists and specialists of allied trade, general practitioners, family physicians and pediatrics.
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