AARDVARK: an automated reversion detector for variants affecting resistance kinetics.

IF 4.4 3区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Bioinformatics Pub Date : 2023-08-01 DOI:10.1093/bioinformatics/btad509

Thaidy Moreno, Joaquin Magana, David A Quigley

引用次数: 0

Abstract

Summary: Resistance to two classes of FDA-approved therapies that target DNA repair-deficient tumors is caused by mutations that restore the tumor cell's DNA repair function. Identifying these "reversion" mutations currently requires manual annotation of patient tumor sequence data. Here we present AARDVARK, an R package that automatically identifies reversion mutations from DNA sequence data.

Availability and implementation: AARDVARK is implemented in R (≥3.5). It is available on GitHub at https://github.com/davidquigley/aardvark. It is licensed under the MIT license.

Abstract Image

查看原文本刊更多论文

AARDVARK：影响抗性动力学变异的自动逆转检测器。

摘要美国 FDA 批准的针对 DNA 修复缺陷肿瘤的两类疗法的抗药性是由恢复肿瘤细胞 DNA 修复功能的突变引起的。目前，识别这些 "逆转 "突变需要对患者肿瘤序列数据进行人工标注。在此，我们介绍一款能从 DNA 序列数据中自动识别逆转突变的 R 软件包 AARDVARK：AARDVARK 由 R (≥3.5) 实现。它可在 GitHub 上获取：https://github.com/davidquigley/aardvark。它采用 MIT 许可。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bioinformatics 生物-生化研究方法

CiteScore

11.20

自引率

5.20%

发文量

753

审稿时长

2.1 months

期刊介绍： The leading journal in its field, Bioinformatics publishes the highest quality scientific papers and review articles of interest to academic and industrial researchers. Its main focus is on new developments in genome bioinformatics and computational biology. Two distinct sections within the journal - Discovery Notes and Application Notes- focus on shorter papers; the former reporting biologically interesting discoveries using computational methods, the latter exploring the applications used for experiments.