Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment.

IF 11.3 1区 医学 Q1 Medicine
Eun Sook Lee, Hyewon Ko, Chan Ho Kim, Hyun-Chul Kim, Seong-Kyoon Choi, Sang Won Jeong, Se-Guen Lee, Sung-Jun Lee, Hee-Kyung Na, Jae Hyung Park, Jung Min Shin
{"title":"Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment.","authors":"Eun Sook Lee, Hyewon Ko, Chan Ho Kim, Hyun-Chul Kim, Seong-Kyoon Choi, Sang Won Jeong, Se-Guen Lee, Sung-Jun Lee, Hee-Kyung Na, Jae Hyung Park, Jung Min Shin","doi":"10.1186/s40824-023-00418-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Exosomes are extracellular vesicles secreted by eukaryotic cells and have been extensively studied for their surface markers and internal cargo with unique functions. A deeper understanding of exosomes has allowed their application in various research areas, particularly in diagnostics and therapy.</p><p><strong>Main body: </strong>Exosomes have great potential as biomarkers and delivery vehicles for encapsulating therapeutic cargo. However, the limitations of bare exosomes, such as rapid phagocytic clearance and non-specific biodistribution after injection, pose significant challenges to their application as drug delivery systems. This review focuses on exosome-based drug delivery for treating rheumatoid arthritis, emphasizing pre/post-engineering approaches to overcome these challenges.</p><p><strong>Conclusion: </strong>This review will serve as an essential resource for future studies to develop novel exosome-based therapeutic approaches for rheumatoid arthritis. Overall, the review highlights the potential of exosomes as a promising therapeutic approach for rheumatoid arthritis treatment.</p>","PeriodicalId":9079,"journal":{"name":"Biomaterials Research","volume":"27 1","pages":"81"},"PeriodicalIF":11.3000,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464174/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomaterials Research","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1186/s40824-023-00418-2","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Exosomes are extracellular vesicles secreted by eukaryotic cells and have been extensively studied for their surface markers and internal cargo with unique functions. A deeper understanding of exosomes has allowed their application in various research areas, particularly in diagnostics and therapy.

Main body: Exosomes have great potential as biomarkers and delivery vehicles for encapsulating therapeutic cargo. However, the limitations of bare exosomes, such as rapid phagocytic clearance and non-specific biodistribution after injection, pose significant challenges to their application as drug delivery systems. This review focuses on exosome-based drug delivery for treating rheumatoid arthritis, emphasizing pre/post-engineering approaches to overcome these challenges.

Conclusion: This review will serve as an essential resource for future studies to develop novel exosome-based therapeutic approaches for rheumatoid arthritis. Overall, the review highlights the potential of exosomes as a promising therapeutic approach for rheumatoid arthritis treatment.

Abstract Image

Abstract Image

Abstract Image

通过裸外泌体或工程外泌体调节疾病微环境治疗类风湿关节炎。
外泌体是由真核细胞分泌的细胞外囊泡,由于其表面标记和内部货物具有独特的功能而被广泛研究。对外泌体的深入了解使它们能够应用于各种研究领域,特别是在诊断和治疗方面。正文:外泌体作为生物标志物和包封治疗货物的递送载体具有巨大的潜力。然而,裸外泌体的局限性,如注射后的快速吞噬清除和非特异性生物分布,对其作为药物递送系统的应用构成了重大挑战。这篇综述的重点是基于外泌体的药物递送治疗类风湿性关节炎,强调前/后工程方法来克服这些挑战。结论:本综述将为未来研究开发新的基于外泌体的类风湿性关节炎治疗方法提供必要的资源。总之,该综述强调了外泌体作为类风湿关节炎治疗的一种有前景的治疗方法的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Biomaterials Research
Biomaterials Research Medicine-Medicine (miscellaneous)
CiteScore
10.20
自引率
3.50%
发文量
63
审稿时长
30 days
期刊介绍: Biomaterials Research, the official journal of the Korean Society for Biomaterials, is an open-access interdisciplinary publication that focuses on all aspects of biomaterials research. The journal covers a wide range of topics including novel biomaterials, advanced techniques for biomaterial synthesis and fabrication, and their application in biomedical fields. Specific areas of interest include functional biomaterials, drug and gene delivery systems, tissue engineering, nanomedicine, nano/micro-biotechnology, bio-imaging, regenerative medicine, medical devices, 3D printing, and stem cell research. By exploring these research areas, Biomaterials Research aims to provide valuable insights and promote advancements in the biomaterials field.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信