Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment.

IF 11.3 1区医学 Q1 Medicine

Biomaterials Research Pub Date : 2023-08-28 DOI:10.1186/s40824-023-00418-2

Eun Sook Lee, Hyewon Ko, Chan Ho Kim, Hyun-Chul Kim, Seong-Kyoon Choi, Sang Won Jeong, Se-Guen Lee, Sung-Jun Lee, Hee-Kyung Na, Jae Hyung Park, Jung Min Shin

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Abstract

Background: Exosomes are extracellular vesicles secreted by eukaryotic cells and have been extensively studied for their surface markers and internal cargo with unique functions. A deeper understanding of exosomes has allowed their application in various research areas, particularly in diagnostics and therapy.

Main body: Exosomes have great potential as biomarkers and delivery vehicles for encapsulating therapeutic cargo. However, the limitations of bare exosomes, such as rapid phagocytic clearance and non-specific biodistribution after injection, pose significant challenges to their application as drug delivery systems. This review focuses on exosome-based drug delivery for treating rheumatoid arthritis, emphasizing pre/post-engineering approaches to overcome these challenges.

Conclusion: This review will serve as an essential resource for future studies to develop novel exosome-based therapeutic approaches for rheumatoid arthritis. Overall, the review highlights the potential of exosomes as a promising therapeutic approach for rheumatoid arthritis treatment.

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通过裸外泌体或工程外泌体调节疾病微环境治疗类风湿关节炎。

外泌体是由真核细胞分泌的细胞外囊泡，由于其表面标记和内部货物具有独特的功能而被广泛研究。对外泌体的深入了解使它们能够应用于各种研究领域，特别是在诊断和治疗方面。正文:外泌体作为生物标志物和包封治疗货物的递送载体具有巨大的潜力。然而，裸外泌体的局限性，如注射后的快速吞噬清除和非特异性生物分布，对其作为药物递送系统的应用构成了重大挑战。这篇综述的重点是基于外泌体的药物递送治疗类风湿性关节炎，强调前/后工程方法来克服这些挑战。结论:本综述将为未来研究开发新的基于外泌体的类风湿性关节炎治疗方法提供必要的资源。总之，该综述强调了外泌体作为类风湿关节炎治疗的一种有前景的治疗方法的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomaterials Research Medicine-Medicine (miscellaneous)

CiteScore

10.20

自引率

3.50%

发文量

审稿时长

30 days

期刊介绍： Biomaterials Research, the official journal of the Korean Society for Biomaterials, is an open-access interdisciplinary publication that focuses on all aspects of biomaterials research. The journal covers a wide range of topics including novel biomaterials, advanced techniques for biomaterial synthesis and fabrication, and their application in biomedical fields. Specific areas of interest include functional biomaterials, drug and gene delivery systems, tissue engineering, nanomedicine, nano/micro-biotechnology, bio-imaging, regenerative medicine, medical devices, 3D printing, and stem cell research. By exploring these research areas, Biomaterials Research aims to provide valuable insights and promote advancements in the biomaterials field.