Simplified and accessible [¹⁸ F]F-AraG synthesis procedure for preclinical PET.

IF 0.9 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2022-08-01 DOI:10.1002/jlcr.3997

Antonia A Högnäsbacka, Miguel A Cortés González, Christer Halldin, Magnus Schou

引用次数: 1

Abstract

The PET tracer [¹⁸ F]F-AraG, an arabinosyl guanine analog, has shown promise for visualizing activated T cells in multiple diseases. Herein, a practitioner's protocol is described, in which the PET tracer is prepared using minimal equipment and manual actions, making it widely accessible for preclinical applications.

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临床前PET的F- arag合成过程的简化和易于获取[18 F]。

PET示踪剂[18 F]F- arag是一种阿拉伯糖基鸟嘌呤类似物，有望在多种疾病中显示活化的T细胞。本文描述了一种医生的方案，其中PET示踪剂是使用最少的设备和手动操作制备的，使其广泛用于临床前应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of labelled compounds & radiopharmaceuticals 医学-分析化学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Labelled Compounds and Radiopharmaceuticals publishes all aspects of research dealing with labeled compound preparation and applications of these compounds. This includes tracer methods used in medical, pharmacological, biological, biochemical and chemical research in vitro and in vivo. The Journal of Labelled Compounds and Radiopharmaceuticals devotes particular attention to biomedical research, diagnostic and therapeutic applications of radiopharmaceuticals, covering all stages of development from basic metabolic research and technological development to preclinical and clinical studies based on physically and chemically well characterized molecular structures, coordination compounds and nano-particles.

Simplified and accessible [18 F]F-AraG synthesis procedure for preclinical PET.

Abstract

Simplified and accessible [¹⁸ F]F-AraG synthesis procedure for preclinical PET.