The Independent Association Between Age and Serum Cholesterol Levels in Patients with Familial Hypercholesterolemia.

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Discovery medicine Pub Date : 2022-11-01

Jinchun He, Yan Wu, Yaodong Wang

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引用次数: 0

Abstract

Background: Studies have suggested that age and the serum total cholesterol (TC) concentration are independent risk factors for cardiovascular disease (CVD) in patients with familial hypercholesterolemia (FH); however, the relationship between age and TC in patients with FH is unclear. We aimed to investigate the correlation between age and TC in patients with FH.

Methods: In this study, 103 patients with FH and 106 non-FH controls were recruited from 2004 to 2017. Spearman and partial correlation analyses, as well as multiple regression analyses, were used to evaluate the relationship between TC and age.

Results: There were no significant differences in age, gender, or BMI between the FH group and the control group (p > 0.05). Family history of CVD, TC, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), lipoprotein (a) (Lp[a]), and non-HDL-C levels were significantly higher in patients with FH compared with the controls (p < 0.01). Additionally, the serum TC levels for ages ≥ 50 years were significantly higher than those for ages < 50 years (p < 0.05) in FH patients. In both Spearman and partial correlation analyses, age was found to be significantly correlated with serum TC (p < 0.001) in the FH group but not in the control group, which was confirmed by further multiple linear regression analyses and logistic regression analyses.

Conclusions: Age is an independent factor influencing serum TC level in patients with FH, and it is necessary to conduct early screening and early intervention.

本刊更多论文

家族性高胆固醇血症患者年龄与血清胆固醇水平的独立关系

背景:研究表明，年龄和血清总胆固醇(TC)浓度是家族性高胆固醇血症(FH)患者发生心血管疾病(CVD)的独立危险因素;然而，FH患者的年龄与TC之间的关系尚不清楚。我们的目的是研究FH患者年龄与TC的相关性。方法:在本研究中，从2004年至2017年招募了103例FH患者和106例非FH对照组。采用Spearman分析、偏相关分析及多元回归分析评价TC与年龄的关系。结果:FH组患者年龄、性别、BMI与对照组比较差异无统计学意义(p > 0.05)。FH患者CVD家族史、TC家族史、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、脂蛋白(a) (Lp[a])、非HDL-C水平均显著高于对照组(p < 0.01)。此外，年龄≥50岁的FH患者血清TC水平显著高于年龄< 50岁的FH患者(p < 0.05)。Spearman分析和偏相关分析均发现，FH组年龄与血清TC显著相关(p < 0.001)，而对照组无显著相关，进一步的多元线性回归分析和logistic回归分析证实了这一点。结论:年龄是影响FH患者血清TC水平的独立因素，早期筛查、早期干预是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Discovery medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Discovery Medicine publishes novel, provocative ideas and research findings that challenge conventional notions about disease mechanisms, diagnosis, treatment, or any of the life sciences subjects. It publishes cutting-edge, reliable, and authoritative information in all branches of life sciences but primarily in the following areas: Novel therapies and diagnostics (approved or experimental); innovative ideas, research technologies, and translational research that will give rise to the next generation of new drugs and therapies; breakthrough understanding of mechanism of disease, biology, and physiology; and commercialization of biomedical discoveries pertaining to the development of new drugs, therapies, medical devices, and research technology.