The role of hyperbaric oxygen in osteoradionecrosis—a prophylactic insight

IF 1.9 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Australian dental journal Pub Date : 2023-06-22 DOI:10.1111/adj.12963

B Dang, S Gamage, S Sethi, ED Jensen, P Sambrook, A Goss

{"title":"The role of hyperbaric oxygen in osteoradionecrosis—a prophylactic insight","authors":"B Dang, S Gamage, S Sethi, ED Jensen, P Sambrook, A Goss","doi":"10.1111/adj.12963","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Osteoradionecrosis (ORN) is an uncommon and debilitating consequence of head and neck radiotherapy and hyperbaric oxygen therapy (HBOT) has been advocated for prophylaxis prior to performing dentoalveolar procedures. The aim of this study was to evaluate a prophylactic HBOT protocol and describe the outcomes of susceptible individuals.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A retrospective audit of adults who attended the Oral and Maxillofacial Surgery department at the Royal Adelaide Hospital (South Australia) who received dental extractions with a history of radiotherapy to the jaws from 2008 to 2020. Data including demographic information and outcomes of osteoradionecrosis and delayed healing was recorded.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 121 individuals were eligible for case note review; 68.6% of individuals were male and 55.4% were aged over 67 years. Osteoradionecrosis occurred in 9.1% of individuals and delayed healing for 3.3%; fifteen individuals (12.4%) were unable to complete the HBOT protocol. The individuals who were diagnosed with ORN had a significant association with age (<i>P</i> = 0.006) and binary analysis showed alcohol consumption to be a significant predictor.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Prophylactic HBOT protocol had a lower proportion of individuals diagnosed with ORN and those who were diagnosed were more likely to be younger males and have current alcohol consumption.</p>\n </section>\n </div>","PeriodicalId":8593,"journal":{"name":"Australian dental journal","volume":"68 3","pages":"171-178"},"PeriodicalIF":1.9000,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adj.12963","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Australian dental journal","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/adj.12963","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Osteoradionecrosis (ORN) is an uncommon and debilitating consequence of head and neck radiotherapy and hyperbaric oxygen therapy (HBOT) has been advocated for prophylaxis prior to performing dentoalveolar procedures. The aim of this study was to evaluate a prophylactic HBOT protocol and describe the outcomes of susceptible individuals.

Methods

A retrospective audit of adults who attended the Oral and Maxillofacial Surgery department at the Royal Adelaide Hospital (South Australia) who received dental extractions with a history of radiotherapy to the jaws from 2008 to 2020. Data including demographic information and outcomes of osteoradionecrosis and delayed healing was recorded.

Results

A total of 121 individuals were eligible for case note review; 68.6% of individuals were male and 55.4% were aged over 67 years. Osteoradionecrosis occurred in 9.1% of individuals and delayed healing for 3.3%; fifteen individuals (12.4%) were unable to complete the HBOT protocol. The individuals who were diagnosed with ORN had a significant association with age (P = 0.006) and binary analysis showed alcohol consumption to be a significant predictor.

Conclusions

Prophylactic HBOT protocol had a lower proportion of individuals diagnosed with ORN and those who were diagnosed were more likely to be younger males and have current alcohol consumption.

Abstract Image

查看原文本刊更多论文

高压氧在骨放射性坏死中的作用——预防性洞察

背景:骨放射性坏死(ORN)是头颈部放射治疗的一种罕见且使人衰弱的后果，高压氧治疗(HBOT)一直被提倡在进行牙槽牙治疗之前进行预防。本研究的目的是评估预防性HBOT方案，并描述易感个体的结果。方法回顾性分析2008年至2020年在南澳大利亚皇家阿德莱德医院口腔颌面外科接受拔牙并有颌部放疗史的成人病例。数据包括人口统计信息和骨放射性坏死和延迟愈合的结果记录。结果共有121人符合病例记录审查条件;68.6%为男性，55.4%年龄在67岁以上。9.1%发生骨坏死，3.3%发生延迟愈合;15人(12.4%)无法完成HBOT方案。被诊断为ORN的个体与年龄有显著相关性(P = 0.006)，二元分析显示饮酒是一个显著的预测因子。结论:预防性HBOT方案诊断为ORN的个体比例较低，被诊断为ORN的个体更可能是年轻男性，并且目前饮酒。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Australian dental journal 医学-牙科与口腔外科

CiteScore

4.20

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The Australian Dental Journal provides a forum for the exchange of information about new and significant research in dentistry, promoting the discipline of dentistry in Australia and throughout the world. It comprises peer-reviewed research articles as its core material, supplemented by reviews, theoretical articles, special features and commentaries.