Chronological changes of lower urinary tract symptoms after low-dose-rate brachytherapy for prostate cancer using SpaceOAR® system

IF 2.7 2区医学 Q2 UROLOGY & NEPHROLOGY

Prostate International Pub Date : 2022-12-01 DOI:10.1016/j.prnil.2022.06.003

Tomoki Taniguchi , Koji Iinuma , Masahiro Nakano , Makoto Kawase , Shinichi Takeuchi , Daiki Kato , Manabu Takai , Keita Nakane , Takuma Ishihara , Masaya Ito , Tomoyasu Kumano , Masayuki Matsuo , Takuya Koie

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引用次数: 1

Abstract

Background

The aim of this study is to investigate chronological changes of lower urinary tract symptoms (LUTS) in patients with prostate cancer who underwent low-dose-rate brachytherapy (LDR-BT) followed by the insertion of SpaceOAR® system (SpaceOAR).

Methods

In this retrospective study, 483 patients with localized prostate cancer underwent LDR-BT at the Gifu University Hospital between August 2004 and December 2020. SpaceOAR was inserted in 30 patients after LDR-BT (SpaceOAR group), and 453 patients received LDR-BT alone (non-SpaceOAR group). The International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS), quality of life due to urinary symptoms (IPSS-QOL), and uroflowmetry (UFM), including maximum flow rate (Qmax), voided volume, and post-voided residual urine (PVR), were evaluated before LDR-BT, and at 1, 3, 6, 9, and 12 months after LDR-BT. The outcomes were chronological changes in IPSS, OABSS, and IPSS-QOL compared to pretreatment values and those of covariates in relation to UFM.

Results

The IPSS, OABSS, IPSS-QOL, Qmax, and voided volume were not significantly associated with either group. According to the PVR interaction effect, the insertion of SpaceOAR was significantly affected by chronological changes in PVR (P = 0.001). Three months after LDR-BT, PVR in the SpaceOAR group was significantly higher than that in the non-SpaceOAR group (49.8 mL vs. 30.5 mL; P = 0.002).

Conclusion

SpaceOAR use may temporally increase PVR; however, IPSS, OABSS, IPSS-QOL, Qmax, and voided volume were not significantly associated with LUTS before and after LDR-BT. The combination of LDR-BT and SpaceOAR may be acceptable for treating patients with prostate cancer regarding the chronological changes in LUTS after brachytherapy.

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使用SpaceOAR®系统低剂量率近距离前列腺癌治疗后下尿路症状的时间变化

本研究的目的是探讨前列腺癌患者在接受低剂量近距离放射治疗(LDR-BT)后插入SpaceOAR®系统(SpaceOAR)后下尿路症状(LUTS)的时间变化。方法在这项回顾性研究中，2004年8月至2020年12月在岐阜大学医院接受LDR-BT治疗的483例局限性前列腺癌患者。30例患者在LDR-BT后置入SpaceOAR (SpaceOAR组)，453例患者单独接受LDR-BT(非SpaceOAR组)。在LDR-BT前、LDR-BT后1、3、6、9和12个月分别评估国际前列腺症状评分(IPSS)、膀胱过度活动症状评分(OABSS)、尿路症状生活质量(IPSS- qol)和尿流测定(UFM)，包括最大流量(Qmax)、排尿量和排尿后残留尿(PVR)。结果是IPSS、OABSS和IPSS- qol与预处理值和与UFM相关的协变量的时间变化。结果两组患者IPSS、OABSS、IPSS- qol、Qmax、空泡量均无显著相关性。根据PVR交互效应，SpaceOAR的插入受PVR的时间变化的显著影响(P = 0.001)。LDR-BT后3个月，SpaceOAR组PVR显著高于非SpaceOAR组(49.8 mL vs. 30.5 mL;p = 0.002)。结论使用空间ar可暂时增加PVR;而LDR-BT前后，IPSS、OABSS、IPSS- qol、Qmax和空腔容积与LUTS无显著相关。从近距离放疗后LUTS的时间变化来看，LDR-BT联合SpaceOAR治疗前列腺癌患者是可以接受的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prostate International Medicine-Urology

CiteScore

4.40

自引率

26.70%

发文量

审稿时长

35 days

期刊介绍： Prostate International (Prostate Int, PI), the official English-language journal of Asian Pacific Prostate Society (APPS), is an international peer-reviewed academic journal dedicated to basic and clinical studies on prostate cancer, benign prostatic hyperplasia, prostatitis, and ...