Nail fold microangiopathy in adolescents with type 1 diabetes: Relation to diabetic vascular complications

IF 1.9 4区医学 Q3 HEMATOLOGY

Microcirculation Pub Date : 2022-05-24 DOI:10.1111/micc.12771

Abeer Ahmed Abdelmaksoud, Shaymaa Maher Daifallah, Nouran Yousef Salah, Ahmed Salah Saber

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引用次数: 3

Abstract

Objectives

Microangiopathy is implicated in the pathogenesis of diabetic vascular complications. Nail fold videocapillaroscopy (NVC) is an easy non-invasive tool of microvasculature assessment. This study compares the NVC changes in adolescents with Type1 diabetes (T1D) to healthy controls and correlates them to diabetic vascular complications.

Methods

Hundred thirty-five adolescents with T1D (disease duration 5 years) were compared to 135 matched controls. Diabetes duration, insulin therapy, fundus, and Toronto clinical scoring system (TCSS) were assessed. Fasting lipids, fraction-C of glycosylated hemoglobin (HbA1C), urinary albumin creatinine ratio (UACR), nerve conduction velocity, and NVC were performed.

Results

NVC changes were found in 120 adolescents with T1D (88.8%). These changes were significantly higher in adolescents with T1D than controls (p < .001). Significant positive relation was found between NVC changes and TCSS (p = .006), diabetes duration (p = .001), HbA1C (0.008), cholesterol (p = .011), LDL (0.016), UACR (p < .001), and nerve conduction velocity (p < .001). Multivariate logistic regression study revealed that diabetic nephropathy and neuropathy were independently associated with NVC changes (p < .001 and p = .007, respectively).

Conclusion

Adolescents with T1D have significantly higher NVC changes than controls. These changes were more evident in those having vascular complications than those without. Thus, NVC can be a potential non-invasive tool for early assessment and follow-up of the microvasculature among adolescents with T1D.

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青少年1型糖尿病甲襞微血管病变:与糖尿病血管并发症的关系

目的微血管病变与糖尿病血管并发症的发病有关。甲襞视频毛细血管镜(NVC)是一种简便、无创的微血管评估工具。本研究比较了青少年1型糖尿病(T1D)与健康对照组的NVC变化，并将其与糖尿病血管并发症联系起来。方法将135名青少年T1D患者(病程5年)与135名匹配对照进行比较。评估糖尿病病程、胰岛素治疗、眼底和多伦多临床评分系统(TCSS)。测定空腹血脂、糖化血红蛋白c分(HbA1C)、尿白蛋白肌酐比(UACR)、神经传导速度、NVC。结果青少年T1D患者中NVC改变120例(88.8%)。这些变化在青少年T1D患者中显著高于对照组(p < .001)。NVC变化与TCSS (p = 0.006)、糖尿病病程(p = 0.001)、HbA1C(0.008)、胆固醇(p = 0.011)、LDL(0.016)、UACR (p < 0.001)、神经传导速度(p < 0.001)呈正相关。多因素logistic回归研究显示，糖尿病肾病和神经病变与NVC变化独立相关(p <0.001和p = .007)。结论青少年T1D患者的NVC变化明显高于对照组。这些变化在有血管并发症的患者中比没有血管并发症的患者更明显。因此，NVC可以作为一种潜在的非侵入性工具，用于T1D青少年微血管的早期评估和随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microcirculation 医学-外周血管病

CiteScore

5.00

自引率

4.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.