Gray Matter Brain Alterations in Type 1 Diabetes - Findings Based on Detailed Phenotyping of Neuropathy Status.

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2022-11-01 DOI:10.1055/a-1835-1877

Suganthiya S Croosu, Tine M Hansen, Johan Røikjer, Carsten D Mørch, Niels Ejskjaer, Jens B Frøkjær

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引用次数: 6

Abstract

Aims: This study investigated brain structure in patients of type 1 diabetes with diabetic peripheral neuropathy (DPN) and type 1 diabetes with neuropathic pain and the associations to clinical, peripheral, and cognitive measurements.

Methods: Sixty individuals with type 1 diabetes and 20 healthy controls were included in the study. Nineteen individuals with type 1 diabetes and neuropathic pain, 19 with type 1 diabetes and DPN, 18 with type 1 diabetes without DPN, and 20 healthy controls were included in the brain analyses. We utilized structural brain magnetic resonance imaging to investigate total and regional gray matter volume.

Results: Significant lower gray matter volume was found in type 1 diabetes with neuropathic pain and in type 1 diabetes without DPN compared to healthy controls (p=0.024 and p=0.019, respectively). Lower insula volume was observed in all three diabetes groups (all p≤0.050). Thalamus and hippocampus volume was lower in type 1 diabetes with neuropathic pain, cerebellum volume was lower in type 1 diabetes with DPN, and somatosensory cortex volume was lower in type 1 diabetes without DPN (all p≤0.018). Attenuated memory was associated with lower gray matter volume in type 1 diabetes with DPN. No associations were found between gray matter volume and clinical/peripheral measurements.

Conclusion: We demonstrated lower gray matter volume in individuals with type 1 diabetes regardless of the presence of DPN and neuropathic pain. Hence, central gray matter alteration was not associated with peripheral alterations.

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1型糖尿病的脑灰质改变-基于神经病变状态的详细表型的发现。

目的:本研究探讨1型糖尿病合并糖尿病周围神经病变(DPN)和1型糖尿病合并神经性疼痛患者的脑结构及其与临床、外周和认知测量的关系。方法:选取60例1型糖尿病患者和20例健康对照者。19名1型糖尿病伴神经性疼痛患者、19名1型糖尿病伴DPN患者、18名1型糖尿病伴DPN患者和20名健康对照者被纳入脑分析。我们利用脑结构磁共振成像研究脑灰质总量和局部灰质体积。结果:与健康对照组相比，伴有神经性疼痛的1型糖尿病和无DPN的1型糖尿病患者的灰质体积显著降低(p=0.024和p=0.019)。三组糖尿病患者的胰岛体积均降低(p均≤0.050)。伴有神经性疼痛的1型糖尿病丘脑和海马体积较低，伴有DPN的1型糖尿病小脑体积较低，无DPN的1型糖尿病体感觉皮质体积较低(p均≤0.018)。1型糖尿病伴DPN患者记忆减退与灰质体积降低相关。灰质体积与临床/外周测量没有关联。结论:我们证明了1型糖尿病患者的灰质体积较低，与DPN和神经性疼痛的存在无关。因此，中枢灰质改变与外周改变无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental and Clinical Endocrinology & Diabetes 医学-内分泌学与代谢

CiteScore

4.10

自引率

5.60%

发文量

审稿时长

3 months

期刊介绍： Publishing outstanding articles from all fields of endocrinology and diabetology, from molecular biology to clinical research, this journal is a brilliant resource. Since being published in English in 1983, the popularity of this journal has grown steadily, reflecting the importance of this publication within its field. Original contributions and short communications appear in each issue along with reviews addressing current topics. In addition, supplementary issues are published each year presenting abstracts or proceedings of national and international scientific meetings. The journal was initially published in German and is still the oldest endocrinological periodical in the German-language market!