Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery.

IF 1.1 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Annals of Thoracic and Cardiovascular Surgery Pub Date : 2022-12-20 DOI:10.5761/atcs.cr.21-00052

Akihiro Sasaki, Tatsuya Kato, Hideki Ujiie, Satoru Wakasa, Setsuyuki Otake, Keisuke Kikuchi, Koichi Ohno

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引用次数: 3

Abstract

Introduction: Stiff-person syndrome (SPS) is a rare autoimmune neurological disorder. Paraneoplastic SPS associated with malignant tumors such as thymoma occurs in approximately 5% of all SPS cases. We present a rare case of thymoma accompanied by SPS successfully treated using surgery.

Presentation of case: A 26-year-old woman presented with lower limbs convulsions and gait disturbance and complained of leg pain. Cerebrospinal fluid and blood test results showed a high level of anti-glutamic acid decarboxylase (GAD) antibodies. Computed tomography showed anterior mediastinal tumor suggestive of a thymoma. She underwent extended thymectomy, and her symptoms gradually improved after surgery. No evidence of recurrent thymoma and SPS has been observed over 44 months.

Conclusion: Surgical treatment would be effective for patients with SPS and thymoma.

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胸腺瘤相关僵硬人综合征经手术成功治疗。

简介:僵硬人综合征(SPS)是一种罕见的自身免疫性神经系统疾病。与恶性肿瘤(如胸腺瘤)相关的副肿瘤性SPS约占所有SPS病例的5%。我们报告一例罕见的胸腺瘤伴SPS成功治疗手术。病例介绍:一名26岁女性，表现为下肢抽搐和步态障碍，主诉腿部疼痛。脑脊液和血液检查结果显示抗谷氨酸脱羧酶(GAD)抗体水平高。计算机断层显示前纵隔肿瘤提示胸腺瘤。她接受了长时间的胸腺切除术，术后症状逐渐好转。44个月没有发现胸腺瘤和SPS复发的证据。结论:手术治疗SPS合并胸腺瘤是有效的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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