Trimester-specific thyroid hormone reference data in Sri Lankan women.

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL
Kamani Dhanushka Liyanarachchi, Dimuthu Tharanga Muthukuda, Udari Apsara Liyanage, Renuka Jayatissa, Lakma Tharindi Subasinghe, Ariyavidana Hareendra Pradeep, Eranga Colombage, Lalana Devi Ranasinghe, Nadun Prabuddha Liyanarachchi, Samantha Ranasinghe, Sarath Lekamwasam, Noel Somasundaram
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引用次数: 0

Abstract

Introduction: Regional differences in thyroid hormones are noted, especially during pregnancy.

Objectives: Establish reference values for thyroid function tests for Sri Lankan pregnant women and to determine their comparability with regional data; and determine the prevalence of 2. Thyroid Peroxidase (TPO) antibody positivity and 3. Iodine deficiency among pregnant women with uncomplicated clinical history.

Methods: A cross-sectional study conducted in antenatal clinics of a tertiary care maternity center recruited a minimum of 56 women in each trimester in a multistep approach to derive an "ideal-reference population"; Participants with clinically manifested thyroid disease, followed by subjects with sonographically abnormal thyroids and finally those at high risk for thyroid disease as shown by positive TPO levels and urine iodine deficiency were excluded in sequence. Thyroid hormones were measured by chemiluminescence in the ideal reference population. Reference ranges were derived using median and 5th and 95th centiles.

Results: Final sample included 369 women. TSH reference ranges of the first (n=64), second (n=188) and third (n=117) trimesters were 0.014-2.77mIU/L, 0.31-3.2 mIU/L and 0.34-3.4 mIU/L, respectively. TPO antibody level showed a weak but significant correlation with TSH (r=0.10,p 0.021) in the final sample. No significant association was found between urine iodine and thyroid function tests.

Conclusions: TSH reference ranges observed in this study are concordant with the Caucasian reference values more than the regional values. Discrepancies in study methodology, defining and selection of reference population and methods employed in measuring thyroid hormones in different studies may have accounted for these differences.

斯里兰卡妇女妊娠特异性甲状腺激素参考数据。
甲状腺激素的区域差异是值得注意的,特别是在怀孕期间。目的:为斯里兰卡孕妇建立甲状腺功能检查的参考值,并确定其与区域数据的可比性;并确定患病率2。甲状腺过氧化物酶(TPO)抗体阳性;无复杂临床史的孕妇碘缺乏。方法:在一家三级保健妇产中心的产前诊所进行的一项横断面研究,以多步骤方法在每个妊娠期招募至少56名妇女,以获得“理想参考人群”;有临床表现的甲状腺疾病受试者,其次是超声检查显示甲状腺异常的受试者,最后是TPO阳性和尿碘缺乏显示甲状腺疾病高风险的受试者。在理想参照人群中,用化学发光法测定甲状腺激素。参考范围采用中位数、第5百分位和第95百分位得出。结果:最终样本包括369名女性。妊娠第一(n=64)、第二(n=188)、第三(n=117)三个阶段的TSH参考范围分别为0.014 ~ 2.77mIU/L、0.31 ~ 3.2 mIU/L和0.34 ~ 3.4 mIU/L。在最终样本中,TPO抗体水平与TSH呈微弱但显著的相关性(r=0.10,p 0.021)。尿碘和甲状腺功能检查之间没有明显的联系。结论:本研究观察到的TSH参考值范围与高加索地区参考值的一致性大于区域参考值。不同研究中在研究方法学、参考人群的定义和选择以及测量甲状腺激素的方法上的差异可能是造成这些差异的原因。
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来源期刊
Ceylon Medical Journal
Ceylon Medical Journal MEDICINE, GENERAL & INTERNAL-
自引率
0.00%
发文量
16
期刊介绍: The Ceylon Medical Journal, is the oldest surviving medical journal in Australasia. It is the only medical journal in Sri Lanka that is listed in the Index Medicus. The CMJ started life way back in 1887 as the organ of the Ceylon Branch of the British Medical Association. Except for a brief period between 1893 and 1904 when it ceased publication, the CMJ or its forbear, the Journal of the Ceylon Branch of the British Medical Association, has been published without interruption up to now. The journal"s name changed to the CMJ in 1954.
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