Survival of children and youth with type 1 diabetes mellitus in Tanzania.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Pediatric Diabetes Pub Date : 2022-12-01 DOI:10.1111/pedi.13425

Edna Siima Majaliwa, Linda Minja, Joel Ndayongeje, Kaushik Ramaiya, Sayoki G Mfinanga, Blandina T Mmbaga

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引用次数: 5

Abstract

Introduction: Survival from type 1 diabetes Mellitus is low in lower-income countries with underdeveloped health systems. Support programs from partners like life for a child (LFAC) and changing diabetes in children (CDiC) were implemented in Tanzania in 2005 to provide diabetes care to children and youth. No evaluation of survival has been done since their implementation.

Objective: To assess the survival of children and youth living with diabetes mellitus (CYLDM) in Tanzania.

Methods: A retrospective data collection from 39 clinics of CYLDM was done by extracting data from the diabetes registry between 1991 and 2019. Three cohort were analyzed (1) Cohort 1991-2004 (pre-implementation), (2) Cohort 2005-2010 (during implementation), and (3) 2011-2019 (after the implementation of LFAC/CDiC). Data were analyzed using STATA-version 14.

Results: A total of 3822 data of CYLDM were extracted, mean age at diagnosis was 13.8 (±5) years. Approximately fifty-one percent (50.8%) were male. The total observation time was 28 years, and the Median duration of diabetes of 5 (IQR2, 8) years. Total death was 95 (3%), with a mean age at death of 17.7 (SD 4.7) years. The last cohort (2011-2019) had more diagnosis 2353 (72.7%), as compared to the <2005 cohort with only 163(5%). The survival improved from 59% before 2005 to 69% in the last cohort (2011-2019).

Conclusion: The implemented programs have facilitated the diagnosis and retention of CYLDM in the health care system. In doing so, it has also increased the survival probability in Tanzania compared to the early 90s.

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坦桑尼亚1型糖尿病儿童和青少年的生存率

在卫生系统不发达的低收入国家，1型糖尿病患者的生存率较低。2005年，坦桑尼亚实施了“儿童生活”(LFAC)和“改变儿童糖尿病”(CDiC)等合作伙伴的支持项目，为儿童和青少年提供糖尿病护理。自实施以来，没有对生存情况进行评估。目的:评估坦桑尼亚儿童和青少年糖尿病患者(CYLDM)的生存率。方法:通过提取1991年至2019年糖尿病登记处的数据，回顾性收集39家CYLDM诊所的数据。分析了三个队列(1)1991-2004队列(实施前)，(2)2005-2010队列(实施中)和(3)2011-2019队列(实施LFAC/CDiC后)。使用STATA-version 14分析数据。结果:共提取CYLDM资料3822例，平均诊断年龄为13.8(±5)岁。大约51%(50.8%)是男性。总观察时间28年，糖尿病中位病程5年(IQR2, 8)。总死亡95例(3%)，平均死亡年龄17.7岁(SD 4.7)。最后一个队列(2011-2019)的诊断为2353例(72.7%)，结论:实施的项目促进了CYLDM在医疗系统中的诊断和保留。在这样做的过程中，与90年代初相比，它也提高了坦桑尼亚的存活率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Diabetes 医学-内分泌学与代谢

CiteScore

6.60

自引率

14.70%

发文量

141

审稿时长

4-8 weeks

期刊介绍： Pediatric Diabetes is a bi-monthly journal devoted to disseminating new knowledge relating to the epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes in childhood and adolescence. The aim of the journal is to become the leading vehicle for international dissemination of research and practice relating to diabetes in youth. Papers are considered for publication based on the rigor of scientific approach, novelty, and importance for understanding mechanisms involved in the epidemiology and etiology of this disease, especially its molecular, biochemical and physiological aspects. Work relating to the clinical presentation, course, management and outcome of diabetes, including its physical and emotional sequelae, is considered. In vitro studies using animal or human tissues, whole animal and clinical studies in humans are also considered. The journal reviews full-length papers, preliminary communications with important new information, clinical reports, and reviews of major topics. Invited editorials, commentaries, and perspectives are a regular feature. The editors, based in the USA, Europe, and Australasia, maintain regular communications to assure rapid turnaround time of submitted manuscripts.