Moderate-to-Vigorous Physical Activity is Related With Retinal Neuronal and Axonal Integrity in Persons With Multiple Sclerosis.

IF 3.7 2区医学 Q1 CLINICAL NEUROLOGY

Neurorehabilitation and Neural Repair Pub Date : 2022-12-01 DOI:10.1177/15459683221131787

Jeongwoon Kim, Rachel E Bollaert, Jonathan Cerna, Brynn C Adamson, Connor M Robbs, Naiman A Khan, Robert W Motl

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引用次数: 2

Abstract

Background: Moderate-to-vigorous physical activity (MVPA) may confer benefits for axonal and/or neuronal integrity in adults with multiple sclerosis (MS).

Purpose: Examine the association between device-measured MVPA with optical coherence tomography (OCT) metrics of retinal nerve fiber layer (RNFL) thickness and total macular volume (TMV) in persons with and without MS.

Methods: Adults with MS (N = 41), along with sex-matched healthy control (HC) participants (N = 79), underwent measurements of retinal morphology via OCT and wore an accelerometer for a period of 7 days as a measure of MVPA.

Results: Persons with MS had significantly lower MVPA, RNFL thickness, and TMV compared with HCs. MVPA was correlated with RNFL (r = .38, P < .01) thickness and TMV (r = .49, P < .01). Hierarchical linear regression analyses indicated that addition of MVPA attenuated the Group effect on RNFL and TMV. MVPA accounted for 8% and 3% of the variance in TMV (β = .343, P < .01) and RNFL thickness (β = .217, P = .03), respectively.

Conclusion: MVPA was positively associated with axonal and neuronal integrity assessed by OCT and partially explained group differences in those metrics. These results present possible future targets for MS management by increasing MVPA.

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中度至剧烈运动与多发性硬化症患者视网膜神经元和轴突完整性有关

背景:中度到剧烈的体力活动(MVPA)可能对多发性硬化症(MS)成人患者的轴突和/或神经元完整性有益。目的:研究仪器测量的MVPA与MS患者和非MS患者视网膜神经纤维层(RNFL)厚度和黄斑总体积(TMV)的光学相干断层扫描(OCT)指标之间的关系。方法:成年MS患者(N = 41)和性别匹配的健康对照(HC)参与者(N = 79)通过OCT测量视网膜形态，并佩戴加速度计7天作为MVPA的测量。结果:与hcc患者相比，MS患者的MVPA、RNFL厚度和TMV明显降低。MVPA与RNFL相关(r =。38、P r =。49, P P = .03)。结论:MVPA与OCT评估的轴突和神经元完整性呈正相关，部分解释了这些指标的组间差异。这些结果提出了通过增加MVPA来治疗多发性硬化的可能目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurorehabilitation and Neural Repair 医学-康复医学

CiteScore

8.30

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Neurorehabilitation & Neural Repair (NNR) offers innovative and reliable reports relevant to functional recovery from neural injury and long term neurologic care. The journal''s unique focus is evidence-based basic and clinical practice and research. NNR deals with the management and fundamental mechanisms of functional recovery from conditions such as stroke, multiple sclerosis, Alzheimer''s disease, brain and spinal cord injuries, and peripheral nerve injuries.