Optimal Protocol of Myocardial Perfusion Imaging for Reduction of Radiation Exposure.

Abstract

The Japanese Circulation Society (JCS) 2021 guideline on radiation safety in cardiology was updated based on the eight best practices for myocardial perfusion single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI), which was determined by panels of international atomic energy agency (IAEA) nuclear cardiology protocols cross-sectional study (INCAPS). Although the guideline recommends to avoid too much ²⁰¹Tl or ²⁰¹Tl/^99mTc dual-isotope protocol, the utilization rate of ²⁰¹Tl for SPECT-MPI in Japan is considerably high compared to other countries. In Japan, protocols using ^99mTc should be appropriately promoted based on the guideline to reduce radiation exposure in SPECT-MPI. Among the eight practices, stress-only imaging is considered to be a useful strategy that contributes to a significant reduction in radiation exposure, and hybrid assessment in combination with rest computed tomography (CT)-MPI is one of the practical application methods.