The onchocerciasis hypothesis of nodding syndrome.

IF 3.8 2区医学 Q1 Medicine

PLoS Neglected Tropical Diseases Pub Date : 2023-08-17 eCollection Date: 2023-08-01 DOI:10.1371/journal.pntd.0011523

Robert Colebunders, Amber Hadermann, Joseph Nelson Siewe Fodjo

引用次数: 2

Abstract

Nodding syndrome (NS) is a phenotypic presentation of onchocerciasis-associated epilepsy (OAE). OAE is an important public health problem in areas with high ongoing Onchocerca volvulus transmission. OAE, including NS, is preventable by strengthening onchocerciasis elimination programs. The presence of tau in OAE postmortem brains could be the consequence of neuroinflammation directly or indirectly induced by O. volvulus. Omics research is needed to investigate whether O. volvulus worms contain a neurotropic virus.

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点头综合征的盘尾丝虫病假说。

结节综合征（NS）是盘尾丝虫病相关癫痫（OAE）的一种表型表现。OAE是一个重要的公共卫生问题，在持续性旋锥虫传播率高的地区。OAE，包括NS，可以通过加强盘尾丝虫病消除计划来预防。tau在OAE死后大脑中的存在可能是由O.volulus直接或间接诱导的神经炎症的结果。需要对奥密克戎进行研究，以调查旋毛虫是否含有嗜神经病毒。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PLoS Neglected Tropical Diseases Medicine-Infectious Diseases

CiteScore

7.40

自引率

10.50%

发文量

723

审稿时长

2-3 weeks

期刊介绍： PLOS Neglected Tropical Diseases publishes research devoted to the pathology, epidemiology, prevention, treatment and control of the neglected tropical diseases (NTDs), as well as relevant public policy. The NTDs are defined as a group of poverty-promoting chronic infectious diseases, which primarily occur in rural areas and poor urban areas of low-income and middle-income countries. Their impact on child health and development, pregnancy, and worker productivity, as well as their stigmatizing features limit economic stability. All aspects of these diseases are considered, including: Pathogenesis Clinical features Pharmacology and treatment Diagnosis Epidemiology Vector biology Vaccinology and prevention Demographic, ecological and social determinants Public health and policy aspects (including cost-effectiveness analyses).