Efficacy of a Combined Intramedullary, Periarticular Injection, and Intraarticular Tranexamic Acid Application on Postoperative Bleeding in Total Knee Arthroplasty: A Retrospective Case-Matched Study.

IF 1.2 Q3 ORTHOPEDICS

Advances in Orthopedics Pub Date : 2022-01-01 DOI:10.1155/2022/9175189

Theerawit Hongnaparak, Khanin Iamthanaporn, Pakjai Tuntarattanapong, Varah Yuenyongviwat

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引用次数: 0

Abstract

Background: Topical tranexamic acid (TXA) has been widely used to reduce postoperative blood loss following total knee replacement (TKA). This study aimed to evaluate the effect of combined intramedullary, periarticular injection, and intraarticular TXA application in patients who underwent TKA as compared to those who did not.

Methods: This was a retrospective case-matched study of 111 patients. We evaluated the transfusion rate and postoperative drainage of 56 patients who underwent TKA using combined topical tranexamic acid application (directly pushed into the femoral intramedullary canal and tibia base, with periarticular soft tissue injection and injected into the knee cavity via a drain tube) and the control group of 55 patients.

Results: In the control and TXA groups, 7.14% and 1.81% of the patients received blood transfusions, respectively (p=0.176). The closed-suction drainage output at 0-8 h and total drainage output were significantly lower in the TXA group than those in the control group (p < 0.001).

Conclusion: Application of topical TXA with the combined method (intramedullary, periarticular injection, and intraarticular) in TKA decreases postoperative suction drainage and may reduce the need for postoperative blood transfusion.

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髓内、关节周注射和关节内联合应用氨甲环酸治疗全膝关节置换术后出血的疗效:回顾性病例匹配研究。

背景:局部氨甲环酸(TXA)已被广泛用于减少全膝关节置换术(TKA)后的术后出血量。本研究旨在评估髓内注射、关节周注射和关节内应用TXA在接受TKA患者中的效果，并与未接受TKA的患者进行比较。方法:对111例患者进行回顾性病例匹配研究。我们对56例经TKA患者采用局部联合氨甲环酸应用(直接推入股髓内管和胫骨基底，关节周围软组织注射，经引流管注入膝关节腔)和对照组55例患者的输血率和术后引流进行了评估。结果:对照组和TXA组患者输血率分别为7.14%和1.81% (p=0.176)。TXA组0 ~ 8 h闭式吸引引流量及总引流量均显著低于对照组(p < 0.001)。结论:局部应用TXA联合髓内注射、关节周注射、关节内注射，可减少TKA术后吸引引流，减少术后输血。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Orthopedics ORTHOPEDICS-

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

21 weeks

期刊介绍： Advances in Orthopedics is a peer-reviewed, Open Access journal that provides a forum for orthopaedics working on improving the quality of orthopedic health care. The journal publishes original research articles, review articles, and clinical studies related to arthroplasty, hand surgery, limb reconstruction, pediatric orthopaedics, sports medicine, trauma, spinal deformities, and orthopaedic oncology.