Ellagic Acid Prevents Oxidative Stress and Memory Deficits in a Rat Model of Scopolamine-induced Alzheimer's Disease.

Q3 Psychology

Central nervous system agents in medicinal chemistry Pub Date : 2022-01-01 DOI:10.2174/1871524923666221027100949

Amir Hossein Assaran, Mahsan Akbarian, Sabiheh Amirahmadi, Hossein Salmani, Shima Shirzad, Mahmoud Hosseini, Farimah Beheshti, Arezoo Rajabian

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引用次数: 3

Abstract

Background: Ellagic acid (EA) has various pharmacological effects such as antiinflammatory and anti-oxidant effects.

Objective: This study aimed to investigate the effects of EA on learning and memory dysfunction as well as oxidative stress in scopolamine-induced amnesic rats.

Methods: The studied rats were treated according to the following protocol: Control (group 1) and scopolamine (group 2) groups received saline (intraperitoneal injection (i.p.)) while the treatment groups (group 3-5) were given EA (25, 50, and 100 mg/kg, i.p.) for 3 weeks. Thereafter, their behavioral performance was evaluated using Morris water maze (MWM) and passive avoidance (PA) tasks. Notably, scopolamine was injected (into groups II-V at a dose of 2 mg/kg, i.p.) before conducting the tasks. Finally, the oxidative stress indicators in the brain were measured.

Results: EA reduced the escape latencies and distances during the learning phase of MWM. The results of probe trials also indicated that EA improved memory retrieval and helped animals recall the platform. Moreover, EA increased delay and light time, while decreasing the frequency of entries to the dark area of PA. In the EA-treated groups, the level of malondialdehyde was decreased, while the levels of total thiol groups, superoxide dismutase, and catalase were increased.

Conclusion: EA prevented the negative effects of scopolamine on learning and memory which is probably mediated via modulating oxidative stress. Hence, EA could be considered as a potential alternative therapy for dementia.

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鞣花酸在东莨菪碱诱导的老年痴呆症大鼠模型中预防氧化应激和记忆缺陷。

背景:鞣花酸具有抗炎、抗氧化等多种药理作用。目的:探讨EA对东莨菪碱致失忆症大鼠学习记忆功能障碍及氧化应激的影响。方法:研究大鼠按以下方案治疗:对照组(1组)和东莨菪碱组(2组)给予生理盐水(腹腔注射(i.p))，治疗组(3 ~ 5组)给予EA(25、50、100 mg/kg, i.p)，疗程3周。随后，采用Morris水迷宫(MWM)和被动回避(PA)任务评估他们的行为表现。值得注意的是，在执行任务之前注射了东莨菪碱(II-V组，剂量为2mg /kg, i.p)。最后，测量脑内氧化应激指标。结果:EA减少了MWM学习阶段的逃避潜伏期和逃避距离。探针试验的结果也表明，EA改善了记忆检索，并帮助动物回忆平台。此外，EA增加了延迟和亮时间，同时减少了进入PA暗区的频率。在ea处理组中，丙二醛水平降低，而总硫醇、超氧化物歧化酶和过氧化氢酶水平升高。结论:EA可抑制东莨菪碱对学习记忆的负面影响，其机制可能与调节氧化应激有关。因此，EA可以被认为是一种潜在的替代治疗痴呆症的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.