Plant-derived polyphenolic compounds: nanodelivery through polysaccharide-based systems to improve the biological properties.

IF 7.3 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Critical reviews in food science and nutrition Pub Date : 2024-11-01 Epub Date: 2023-08-10 DOI:10.1080/10408398.2023.2245038

Thiécla Katiane Osvaldt Rosales, Fábio Fernando Alves da Silva, Emerson Soares Bernardes, João Paulo Fabi

{"title":"Plant-derived polyphenolic compounds: nanodelivery through polysaccharide-based systems to improve the biological properties.","authors":"Thiécla Katiane Osvaldt Rosales, Fábio Fernando Alves da Silva, Emerson Soares Bernardes, João Paulo Fabi","doi":"10.1080/10408398.2023.2245038","DOIUrl":null,"url":null,"abstract":"<p><p>Plant-derived polyphenols are naturally occurring compounds widely distributed in plants. They have received greater attention in the food and pharmaceutical industries due to their potential health benefits, reducing the risk of some chronic diseases due to their antioxidant, anti-inflammatory, anticancer, cardioprotective, and neuro-action properties. Polyphenolic compounds orally administered can be used as adjuvants in several treatments but with restricted uses due to chemical instability. The review discusses the different structural compositions of polyphenols and their influence on chemical stability. Despite the potential and wide applications, there is a need to improve the delivery of polyphenolics to target the human intestine without massive chemical modifications. Oral administration of polyphenols is unfeasible due to instability, low bioaccessibility, and limited bioavailability. Nano-delivery systems based on polysaccharides (starch, pectin, chitosan, and cellulose) have been identified as a viable option for oral ingestion, potentiate biological effects, and direct-controlled delivery in specific tissues. The time and dose can be individualized for specific diseases, such as intestinal cancer. This review will address the mechanisms by which polysaccharides-based nanostructured systems can protect against degradation and enhance intestinal permeation, oral bioavailability, and the potential application of polysaccharides as nanocarriers for the controlled and targeted delivery of polyphenolic compounds.</p>","PeriodicalId":10767,"journal":{"name":"Critical reviews in food science and nutrition","volume":" ","pages":"11894-11918"},"PeriodicalIF":7.3000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical reviews in food science and nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1080/10408398.2023.2245038","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/10 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Plant-derived polyphenols are naturally occurring compounds widely distributed in plants. They have received greater attention in the food and pharmaceutical industries due to their potential health benefits, reducing the risk of some chronic diseases due to their antioxidant, anti-inflammatory, anticancer, cardioprotective, and neuro-action properties. Polyphenolic compounds orally administered can be used as adjuvants in several treatments but with restricted uses due to chemical instability. The review discusses the different structural compositions of polyphenols and their influence on chemical stability. Despite the potential and wide applications, there is a need to improve the delivery of polyphenolics to target the human intestine without massive chemical modifications. Oral administration of polyphenols is unfeasible due to instability, low bioaccessibility, and limited bioavailability. Nano-delivery systems based on polysaccharides (starch, pectin, chitosan, and cellulose) have been identified as a viable option for oral ingestion, potentiate biological effects, and direct-controlled delivery in specific tissues. The time and dose can be individualized for specific diseases, such as intestinal cancer. This review will address the mechanisms by which polysaccharides-based nanostructured systems can protect against degradation and enhance intestinal permeation, oral bioavailability, and the potential application of polysaccharides as nanocarriers for the controlled and targeted delivery of polyphenolic compounds.

查看原文本刊更多论文

植物源多酚化合物：通过基于多糖的纳米输送系统改善生物特性。

植物多酚是广泛分布于植物中的天然化合物。由于具有抗氧化、抗炎、抗癌、保护心脏和神经作用等特性，它们可以降低患某些慢性疾病的风险，因此在食品和制药行业受到越来越多的关注。口服多酚化合物可用作多种治疗方法的辅助剂，但由于化学性质不稳定，其用途受到限制。本综述讨论了多酚的不同结构组成及其对化学稳定性的影响。尽管多酚具有巨大的潜力和广泛的应用，但仍有必要在不对其进行大规模化学修饰的情况下，改进以人体肠道为靶点的多酚给药方式。由于多酚的不稳定性、低生物可及性和有限的生物利用度，口服多酚是不可行的。以多糖（淀粉、果胶、壳聚糖和纤维素）为基础的纳米给药系统被认为是一种可行的选择，它可以口服、增强生物效应并直接控制在特定组织中的给药。针对肠癌等特定疾病，可以对时间和剂量进行个体化。本综述将探讨以多糖为基础的纳米结构体系可防止降解、增强肠道渗透性、提高口服生物利用度的机制，以及多糖作为纳米载体在控制和靶向递送多酚化合物方面的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Critical reviews in food science and nutrition 工程技术-食品科技

CiteScore

22.60

自引率

4.90%

发文量

600

审稿时长

7.5 months

期刊介绍： Critical Reviews in Food Science and Nutrition serves as an authoritative outlet for critical perspectives on contemporary technology, food science, and human nutrition. With a specific focus on issues of national significance, particularly for food scientists, nutritionists, and health professionals, the journal delves into nutrition, functional foods, food safety, and food science and technology. Research areas span diverse topics such as diet and disease, antioxidants, allergenicity, microbiological concerns, flavor chemistry, nutrient roles and bioavailability, pesticides, toxic chemicals and regulation, risk assessment, food safety, and emerging food products, ingredients, and technologies.