Analyzing the glial proteome in Alzheimer's disease.

IF 3.8 3区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Expert Review of Proteomics Pub Date : 2023-07-01 Epub Date: 2023-10-27 DOI:10.1080/14789450.2023.2260955

Jong-Heon Kim, Ruqayya Afridi, Won-Ha Lee, Kyoungho Suk

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引用次数: 0

Abstract

Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, memory loss, and changes in behavior. Accumulating evidence indicates that dysfunction of glial cells, including astrocytes, microglia, and oligodendrocytes, may contribute to the development and progression of AD. Large-scale analysis of glial proteins sheds light on their roles in cellular processes and diseases. In AD, glial proteomics has been utilized to understand glia-based pathophysiology and identify potential biomarkers and therapeutic targets.

Area covered: In this review, we provide an updated overview of proteomic analysis of glia in the context of AD. Additionally, we discuss current challenges in the field, involving glial complexity and heterogeneity, and describe some cutting-edge proteomic technologies to address them.

Expert opinion: Unbiased comprehensive analysis of glial proteomes aids our understanding of the molecular and cellular mechanisms of AD pathogenesis. These investigations highlight the crucial role of glial cells and provide novel insights into the mechanisms of AD pathology. A deeper understanding of the AD-related glial proteome could offer a repertoire of potential biomarkers and therapeutics. Further technical advancement of glial proteomics will enable us to identify proteins within individual cells and specific cell types, thus significantly enhancing our comprehension of AD pathogenesis.

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阿尔茨海默病的神经胶质蛋白质组分析。

引言：阿尔茨海默病（AD）是一种神经退行性疾病，其特征是进行性认知能力下降、记忆力丧失和行为改变。越来越多的证据表明，包括星形胶质细胞、小胶质细胞和少突胶质细胞在内的神经胶质细胞的功能障碍可能有助于AD的发展和进展。对神经胶质蛋白的大规模分析揭示了它们在细胞过程和疾病中的作用。在AD中，神经胶质蛋白质组学已被用于了解基于神经胶质的病理生理学，并确定潜在的生物标志物和治疗靶点。涵盖领域：在这篇综述中，我们提供了AD背景下神经胶质蛋白质组学分析的最新概述。此外，我们讨论了该领域当前的挑战，包括神经胶质的复杂性和异质性，并描述了一些尖端的蛋白质组学技术来解决这些挑战。专家意见：对胶质细胞蛋白质组进行无偏的全面分析有助于我们理解AD发病机制的分子和细胞机制。这些研究强调了神经胶质细胞的关键作用，并为AD病理机制提供了新的见解。对AD相关神经胶质蛋白质组的深入了解可以提供一系列潜在的生物标志物和治疗方法。神经胶质蛋白质组学的进一步技术进步将使我们能够识别单个细胞和特定细胞类型中的蛋白质，从而显著增强我们对AD发病机制的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Proteomics 生物-生化研究方法

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Expert Review of Proteomics (ISSN 1478-9450) seeks to collect together technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease. The journal coverage includes, but is not limited to, overviews of specific technological advances in the development of protein arrays, interaction maps, data archives and biological assays, performance of new technologies and prospects for future drug discovery. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion - a personal view on the most effective or promising strategies and a clear perspective of future prospects within a realistic timescale Article highlights - an executive summary cutting to the author''s most critical points.