High Seropositivity of Markers of Viral Infections among Women with Unfavorable Pregnancy Outcomes in Mwanza, Tanzania: The Urgent Need for Control Interventions.

The East African health research journal Pub Date : 2023-01-01 Epub Date: 2023-07-12 DOI:10.24248/eahrj.v7i1.705

Ulimbakisye Mcdonald, Helmut Nyawale, Alphaxard Kajura, Fridolin Mujuni, Elieza Chibwe, Vitus Silago, Betrand Msemwa, Caroline A Minja, Zawadi Daffa, Mahmud Karim, Evidence C Byasharila, Alda Ester Chongo, Stephen E Mshana, Mariam M Mirambo

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Abstract

Background: Viral infections such as Human cytomegalovirus (HCMV), Rubella virus (RV) and Herpes simplex virus-2(HSV-2) are implicated in causing adverse pregnancy outcomes with limited data from Africa. Here we report the magnitude of these viruses among women with unfavorable pregnancy outcomes (WUP) in Mwanza, Tanzania.

Methods: A cross sectional study involving 198 WUP was conducted between March and June 2019 in Mwanza. Enzyme linked immunosorbent assay was used to detect HCMV and RV IgM and IgG antibodies while immunochromatographic test was used to detect HSV-2 IgM and IgG antibodies. Data were analyzed by using STATA version13.0.

Results: The median age of enrolled women was 28(IQR, 24-34) years. Of these 194(98%) were HCMV IgG seropositive while only 2(2.1%) were IgM seropositive. Out of 180 women tested for RV, 175(96.7%) were IgG seropositive while only 1(1.2%) was RV IgM seropositive. Regarding HSV2; out of the 146 women tested, 21(14.4%) were seropositive for HSV2 IgG, and only 3(2.1%) were HSV-2 IgM seropositive. Having primary education (p=.046) and being married (p=.035) were significantly associated with HSV-2 IgG seropositivity.

Conclusion: A substantial proportion of WUP have markers of viral infections for potential pathogens that might be associated with unfavorable pregnancy outcomes necessitating further studies to establish causal effect relationship.

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坦桑尼亚姆万扎妊娠结局不良妇女的病毒感染标记物血清阳性率很高：迫切需要采取控制干预措施。

背景：人类巨细胞病毒（HCMV）、风疹病毒（RV）和单纯疱疹病毒-2（HSV-2）等病毒感染被认为可导致不良妊娠结局，但来自非洲的数据有限。在此，我们报告了这些病毒在坦桑尼亚姆万扎的不良妊娠结局（WUP）妇女中的流行程度：方法：2019 年 3 月至 6 月在姆万扎进行了一项横断面研究，涉及 198 名 WUP。使用酶联免疫吸附试验检测HCMV和RV IgM和IgG抗体，使用免疫层析试验检测HSV-2 IgM和IgG抗体。数据采用 STATA13.0 版进行分析：入组女性的中位年龄为 28（IQR，24-34）岁。其中 194 人（98%）HCMV IgG 血清阳性，只有 2 人（2.1%）IgM 血清阳性。在接受 RV 检测的 180 名妇女中，175 人（96.7%）IgG 血清阳性，只有 1 人（1.2%）RV IgM 血清阳性。关于 HSV2，在接受检测的 146 名妇女中，21 人（14.4%）的 HSV2 IgG 血清呈阳性，只有 3 人（2.1%）的 HSV-2 IgM 血清呈阳性。受过初等教育（p=.046）和已婚（p=.035）与 HSV-2 IgG 血清阳性显著相关：结论：相当大比例的WUP具有潜在病原体的病毒感染标记物，这可能与不利的妊娠结局有关，因此有必要进一步研究以确定因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The East African health research journal

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