Remimazolam for sedation: A protocol for a systematic review with meta-analysis, trial sequential analysis, and GRADE approach.

IF 1.9 4区 医学 Q2 ANESTHESIOLOGY
Acta Anaesthesiologica Scandinavica Pub Date : 2023-11-01 Epub Date: 2023-08-14 DOI:10.1111/aas.14316
Lasse Stehr-Pingel, Mathias Maagaard, Casper Duevang Tvarnø, Lars Peter Kloster Andersen, Jakob Hessel Andersen, Ole Mathiesen
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引用次数: 0

Abstract

Procedural sedation aims to facilitate a successful diagnostic or therapeutic procedure. The pharmacokinetic properties and pharmacodynamic effects need to be taken into consideration when choosing the ideal sedative. Midazolam and propofol are frequently employed. However, they are associated with respiratory depression with increasing dosage. Also, midazolam has a potentially unpredictable pharmacodynamic response and propofol may cause hypotension and injection site pain. Remimazolam may provide a superior alternative due to its rapid pharmacodynamic profile and insignificant circulatory effects.
Remimazolam用于镇静:一项采用荟萃分析、试验序列分析和GRADE方法进行系统综述的方案。
背景:手术镇静旨在促进诊断或治疗程序的成功。在选择理想的镇静剂时,需要考虑药代动力学特性和药效学效应。常用咪唑安定和丙泊酚。然而,随着剂量的增加,它们与呼吸抑制有关。此外,咪达唑仑具有潜在的不可预测的药效反应,丙泊酚可能导致低血压和注射部位疼痛。Remimazolam由于其快速的药效学特征和微不足道的循环作用,可能提供一种优越的替代品。方法:本方案采用系统评价首选报告项目和荟萃分析指南。该综述旨在评估雷咪唑仑与安慰剂或其他镇静剂相比,在诊断或治疗程序或其他情况下需要镇静的成年患者中的有益和有害临床效果。确定了三个主要结果:镇静成功率、呼吸系统并发症和血液动力学并发症。确定了六个次要结果:其中包括恢复质量和严重不良事件。包括所有随机试验。搜索策略包括六个主要的生物医学数据库。文献筛选和数据提取将由两位作者独立进行。系统错误的风险将使用偏差风险2工具进行评估。随机误差的风险将通过试验序列分析进行评估。异质性将通过适当的统计测试进行评估。证据的确定性将通过建议评估、发展和评估的分级来判断。将与Rstudio一起进行荟萃分析。我们将提供一份“调查结果汇总”表,其中包括我们的主要和次要结果。讨论:本方案中概述的最新方法的系统综述调查了雷米唑仑与手术镇静相关的临床效果。该结果可指导临床医生临床使用雷米唑仑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.30
自引率
9.50%
发文量
157
审稿时长
3-8 weeks
期刊介绍: Acta Anaesthesiologica Scandinavica publishes papers on original work in the fields of anaesthesiology, intensive care, pain, emergency medicine, and subjects related to their basic sciences, on condition that they are contributed exclusively to this Journal. Case reports and short communications may be considered for publication if of particular interest; also letters to the Editor, especially if related to already published material. The editorial board is free to discuss the publication of reviews on current topics, the choice of which, however, is the prerogative of the board. Every effort will be made by the Editors and selected experts to expedite a critical review of manuscripts in order to ensure rapid publication of papers of a high scientific standard.
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