Dietary habits and Helicobacter pylori infection: is there an association?

IF 4.2 3区医学

Therapeutic Advances in Gastroenterology Pub Date : 2023-01-01 DOI:10.1177/17562848231160620

Giovana Alice Sampaio Soares, Felipe Augusto de Sousa Moraes, Amanda Ferreira Paes Landim Ramos, Silvana Barbosa Santiago, Janaina Naiara Germano, Gisele Aparecida Fernandes, Maria Paula Curado, Mônica Santiago Barbosa

{"title":"Dietary habits and Helicobacter pylori infection: is there an association?","authors":"Giovana Alice Sampaio Soares, Felipe Augusto de Sousa Moraes, Amanda Ferreira Paes Landim Ramos, Silvana Barbosa Santiago, Janaina Naiara Germano, Gisele Aparecida Fernandes, Maria Paula Curado, Mônica Santiago Barbosa","doi":"10.1177/17562848231160620","DOIUrl":null,"url":null,"abstract":"Background: Helicobacter pylori (H. pylori) is a group 1 carcinogen and the etiological agent of gastric diseases such as gastritis, ulcers, and gastric cancer. It infects approximately half of the world's population. Risk factors associated with H. pylori infection include socioeconomic status, lifestyle, and diet.Objectives: This study aimed to evaluate the association between eating habits and H. pylori infection in patients from a reference hospital in Central Brazil.Design: This cross-sectional study included 156 patients from 2019 to 2022.Methods: Data were collected using a structured questionnaire on sociodemographic and lifestyle characteristics and a validated food frequency questionnaire. The H. pylori infection status (positive versus negative) was determined using the histopathological method. After grams/day, foods were stratified into tertiles of consumption (low, medium, and high). Simple and multiple binary logistic regression models were used in the analysis of odds ratios (ORs) and their respective 95% confidence intervals (CIs), with a 5% significance level.Results: The prevalence of H. pylori infection was 44.2% (69/156 patients). Infected individuals had a mean age of 49.6 ± 14.6 years; 40.6% were men, 34.8% were aged 60 years or older, 42.0% were unmarried, 7.2% had higher education, 72.5% were non-white, and 30.4% were obese. In the H. pylori-positive group, 55.1% were alcohol drinkers and 42.0% were smokers. The results of multiple analyses showed that the chance of H. pylori infection was higher among male participants (OR = 2.25; CI = 1.09-4.68) and individuals with obesity (OR = 2.68; CI = 1.10-6.51). Participants with moderate consumption of refined grains (bread, cookies, cakes, breakfast cereal) (OR = 2.41; CI = 1.04-5.62) and fruits (OR = 2.53; CI = 1.08-5.94) were more likely to be infected.Conclusion: In this study, male sex, obesity, and the consumption of refined grains and fruits were positively associated with H. pylori infection. Further research is needed to investigate this association and elucidate the underlying mechanisms.","PeriodicalId":23022,"journal":{"name":"Therapeutic Advances in Gastroenterology","volume":"16 ","pages":"17562848231160620"},"PeriodicalIF":4.2000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8d/99/10.1177_17562848231160620.PMC10262674.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Advances in Gastroenterology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/17562848231160620","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Helicobacter pylori (H. pylori) is a group 1 carcinogen and the etiological agent of gastric diseases such as gastritis, ulcers, and gastric cancer. It infects approximately half of the world's population. Risk factors associated with H. pylori infection include socioeconomic status, lifestyle, and diet.

Objectives: This study aimed to evaluate the association between eating habits and H. pylori infection in patients from a reference hospital in Central Brazil.

Design: This cross-sectional study included 156 patients from 2019 to 2022.

Methods: Data were collected using a structured questionnaire on sociodemographic and lifestyle characteristics and a validated food frequency questionnaire. The H. pylori infection status (positive versus negative) was determined using the histopathological method. After grams/day, foods were stratified into tertiles of consumption (low, medium, and high). Simple and multiple binary logistic regression models were used in the analysis of odds ratios (ORs) and their respective 95% confidence intervals (CIs), with a 5% significance level.

Results: The prevalence of H. pylori infection was 44.2% (69/156 patients). Infected individuals had a mean age of 49.6 ± 14.6 years; 40.6% were men, 34.8% were aged 60 years or older, 42.0% were unmarried, 7.2% had higher education, 72.5% were non-white, and 30.4% were obese. In the H. pylori-positive group, 55.1% were alcohol drinkers and 42.0% were smokers. The results of multiple analyses showed that the chance of H. pylori infection was higher among male participants (OR = 2.25; CI = 1.09-4.68) and individuals with obesity (OR = 2.68; CI = 1.10-6.51). Participants with moderate consumption of refined grains (bread, cookies, cakes, breakfast cereal) (OR = 2.41; CI = 1.04-5.62) and fruits (OR = 2.53; CI = 1.08-5.94) were more likely to be infected.

Conclusion: In this study, male sex, obesity, and the consumption of refined grains and fruits were positively associated with H. pylori infection. Further research is needed to investigate this association and elucidate the underlying mechanisms.

Abstract Image

查看原文本刊更多论文

饮食习惯与幽门螺杆菌感染有关系吗?

背景:幽门螺杆菌(Helicobacter pylori, H. pylori)是一类致癌物，是胃炎、溃疡、胃癌等胃疾病的病原。它感染了世界上大约一半的人口。与幽门螺杆菌感染相关的危险因素包括社会经济地位、生活方式和饮食。目的:本研究旨在评估巴西中部一家参考医院患者的饮食习惯与幽门螺杆菌感染之间的关系。设计:本横断面研究包括156例2019 - 2022年的患者。方法:采用结构化的社会人口学和生活方式特征问卷和有效的食物频率问卷收集数据。采用组织病理学方法确定幽门螺杆菌感染状态(阳性与阴性)。以克/天为单位，将食物按消耗量(低、中、高)分层。采用简单和多元二元logistic回归模型分析优势比(ORs)及其95%置信区间(ci)，显著性水平为5%。结果:幽门螺杆菌感染率为44.2%(69/156)。感染者平均年龄49.6±14.6岁;40.6%为男性，34.8%为60岁及以上，42.0%为未婚，7.2%为高学历，72.5%为非白人，30.4%为肥胖。在幽门螺杆菌阳性组中，55.1%为饮酒者，42.0%为吸烟者。多重分析结果显示，男性参与者感染幽门螺杆菌的几率更高(OR = 2.25;CI = 1.09-4.68)和肥胖个体(OR = 2.68;ci = 1.10-6.51)。适度食用精制谷物(面包、饼干、蛋糕、早餐麦片)的参与者(OR = 2.41;CI = 1.04-5.62)和水果(OR = 2.53;CI = 1.08-5.94)更容易被感染。结论:在本研究中，男性、肥胖、食用精制谷物和水果与幽门螺杆菌感染呈正相关。需要进一步的研究来调查这种关联并阐明潜在的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Therapeutic Advances in Gastroenterology Medicine-Gastroenterology

自引率

2.40%

发文量

103

期刊介绍： Therapeutic Advances in Gastroenterology is an open access journal which delivers the highest quality peer-reviewed original research articles, reviews, and scholarly comment on pioneering efforts and innovative studies in the medical treatment of gastrointestinal and hepatic disorders. The journal has a strong clinical and pharmacological focus and is aimed at an international audience of clinicians and researchers in gastroenterology and related disciplines, providing an online forum for rapid dissemination of recent research and perspectives in this area. The editors welcome original research articles across all areas of gastroenterology and hepatology. The journal publishes original research articles and review articles primarily. Original research manuscripts may include laboratory, animal or human/clinical studies – all phases. Letters to the Editor and Case Reports will also be considered.